Author: Vkopirait
Peptides are a sequence of amino acids connected by amide (peptide) bonds. Polypeptides are isolated (from a multitude - more than 100 - amino acids), oligopeptides (no more than 50-100) and simple peptides(up to 10 amino acids). From the perspective of a peptide, an amino acid is a monomer unit, or simply a monomer. The limiting case of a peptide - a protein - is a chain of amino acids, which includes over 6000 monomers. Such a classification is conditional. From the point of view of a practicing bodybuilder, it is important to divide peptides into those that contribute to the set muscle mass, and those that lead to weight loss (increased fat burning). Most of them have both effects at the same time, but with different effects. The subject of this article will be peptides for gaining muscle mass:
- GHRP-6 (hexarelin, HEX)- Growth hormone (somatotropin) secretion stimulator. Developed for the treatment of diseases caused or accompanied by a deficiency of this hormone. Does not cause an increase in appetite and an increase in the production of cortisol and prolactin. With the simultaneous use of GHRP-6 and GHRP-2, a synergistic effect is observed. The peptide is used by many athletes to improve endurance in training and to get more relief. appearance. The action is directed directly to the pituitary gland. In addition to the secretion of growth hormone, the production of insulin-like growth factor (IGF-1) is stimulated. Side effect is increased burning subcutaneous fat, reduced recovery time after training, etc.
- GHRP-2- another peptide that releases somatotropin, is classified as an oligopeptide and is recognized as one of the most powerful growth hormone stimulants. Side effects are the production of cortisol and prolactin, as well as increased appetite. It directly affects the pituitary gland, stimulating it to produce somatotropin in amounts that are 7-15 times higher than the “normal state” (in terms of efficiency, this makes GHRP-2 related to a direct injection of somatotropin). The action of the peptide affects the hypothalamus, activates ghrelin receptors (this explains the increasing appetite). It is believed that co-administration with GHRP-6 eliminates these shortcomings.
- ipamorelin- a peptide that enhances the secretion of growth hormone, belongs to the latest generation of drugs to stimulate the production of somatotropin. Directly enhances the production of growth hormone, and also inhibits the action of somatostatin (a hormone that inhibits the secretion of somatotropin). Does not provoke the emergence and strengthening of hunger, does not lead to the production of cortisol and prolactin (the former is a catabolic hormone that destroys muscle tissue and in in large numbers formed in the body after exercise, and the second provokes the manifestation of such effects as gynecomastia, decreased libido)
- GRF(1-29), sermorelin - like the peptides listed above, it sets a “program” for peak production of growth hormone (after which its production is restored to its original values). Taking the drug is an alternative to the course of growth hormone therapy. There is a synergistic effect with the combined use of GFR (1-29), GHRP-6, GHRP-2 and ipamorelin
- CJC-1295- a peptide, identical in action to somatoliberin, enhances the production of somatotropin. Somatoliberin is two peptides, one of 40 amino acids, and the second of 44, acting directly on the pituitary gland (the pituitary gland is responsible for the synthesis of growth hormone)
- gonadorelin- a stimulator of the secretion of luteinizing hormone (which in turn provokes leidigo cells to produce testosterone). A drug based on gonadorelin was developed as a replacement for synthetic testosterone. Gonadorelin, through increased production of follicle-stimulating hormone, improves the functioning of the testicles, which also enhances the secretion of testosterone (at the same time, aromatization - the conversion of testosterone into estradiol - does not go beyond the "norm"). Side effects: normalization of sexual function
- PEG-MGF, pegylated mechanical growth factor - stimulates the division of myoblasts, satellite cells muscle tissue, muscle fiber precursors (triggering hyperplasia). Influences various receptors of muscle cells. MGF itself has a short half-life (only a few minutes), and pegylation serves the purpose of stabilizing the drug. Side effects of mechanical growth factor is the acceleration of recovery after physical activity and increased endurance in training
- oxytocin- hormone of the hypothalamus, peptide. Helps maintain muscle mass by inhibiting cortisol secretion
- glucagon- increases the availability of key energy sources, helping to increase the duration and intensity of training. Enhances the secretion of catelohamins, which stimulate the pituitary and hypothalamus. The presence of catelochamins is a necessary condition for the adaptation of the body to physical activity.
Peptides, unlike synthetic hormones (somatotropin, insulin-like growth factor and testosterone), have no negative side effects in the form of gynecomastia, inhibition of the activity of the testicles, aromatization of testosterone. Their action is aimed at stimulating the body's internal resources for the production of androgenic anabolic hormones. Distinctive feature- it is impossible to say with certainty how much growth hormone, testosterone or IGF-1 will be produced in response to the use of a given amount of a particular drug.
The indirect effects on the set of muscle mass of peptides include:
- strengthening ligaments and preventing their injuries and diseases. Healthy strong ligaments are an opportunity to work with big and big weights which favorably affects the growth of muscle mass
- acceleration of healing of microtraumas and damage to muscle tissue (this property is especially pronounced in hexarelin)
- stimulation of the pituitary gland, in particular - overcoming the inhibition of the body's own ability to synthesize somatotropin (usually caused by abuse using synthetic sources of growth hormone)
- improvement of the bone tissue condition - the bones grow after the muscle mass (they become denser), which is a necessary condition for the continued increase in muscle volume (bone strength is one of the limitations in gaining body weight)
- strengthening of immunity - less absence of workouts due to diseases, less diseases themselves, when the body is forced to mobilize all resources to suppress infection, bacteria, viruses, removing them from anabolic and anti-catabolic processes
- sleep normalization (for example, CJC-1295).
Currently, over 1500 peptides are known to science. Most of them are synthesized. Experts note an increased need for peptides from outside for the following categories of people: patients (with impaired pituitary gland function), children and adolescents, the elderly, and athletes.
To have a beautiful, harmoniously developed body, an integrated approach is needed. For bodybuilders, this is not only correct organized training and a balanced diet, but also special supplements.
The main role in stimulating the growth of muscle mass and increasing the endurance of the body is occupied by hormones, but their intake is not always harmless.
With an excess of hormones, when they come from outside, the body's own glands can stop producing them and atrophy.
In bodybuilding, peptides are used as effective analogues of hormonal anabolics.
They contribute to the restoration of cells and various tissues of the body, including muscle fibers.
Why "peptides"?
Peptides- organic compounds consisting of a sequence of amino acids connected by a peptide bond. Currently, they are well studied, are the product of artificial synthesis and are widely used in medicine, pharmacology, and cosmetology.
From the point of view of benefits for bodybuilding, peptides are usually divided into structural and functional.
- Structural peptides are broken down in the body to their bases, and then their own protein is synthesized from the resulting amino acids. Compared to simple proteins, peptides are absorbed by the body easier and faster. Structural peptides enrich the body with the corresponding amino acids, stimulate anabolism, but have some side effects: possible protein poisoning, the development and growth of muscles when taken ahead of the development of ligaments.
- Functional peptides absorbed by the body in the original form in which they enter it. They can be conditionally divided into means for muscle growth and means for weight loss. Most of them have both at the same time. When discussing the role of peptides in bodybuilding, as a rule, they have in mind functional compounds. They stimulate the production of growth hormone and testosterone hormone, speed up metabolism, activate muscle mass growth, strengthen ligaments. However, their side effects is the unpredictability of the effect. The same dosage can give completely different effects in different athletes. The increase in growth hormone secretion can vary from twofold to sevenfold and even 15-fold. It is also possible that the peptide will not be absorbed at all and will simply be excreted from the body.
Nevertheless, peptides have a number of advantages over artificial growth hormones.
Benefits of peptides over growth hormones
Currently, peptides have gained wide popularity, the action of which is aimed at stimulating the secretion of growth hormone.
Popular peptides
Among the popular peptides, the following groups can be distinguished:
Ghrelin Group (GHRP)
The main feature of this group of drugs is that an increase in the level and peak concentration of growth hormone is observed immediately after administration, regardless of the time of day and the presence of the somatostatin hormone in the blood.
This group includes:
- GHRP-2
- GHRP-6 and Hexarelin
- Ipamorelin
is able to enter the body through the mucous membrane of the oral cavity, which avoids injections, and enters the bloodstream, bypassing the liver. Its main effects:
GHRP-6 similar in properties and effect to GHRP-2, although inferior to him in the effectiveness of stimulating growth hormone. Their main difference is that GHRP-6 has less effect on appetite. These two peptides can be used together to achieve a synergistic effect.
With their joint administration, the maximum concentration of growth hormone in the blood is fixed.
Hexarelin is a structural analogue of GHRP-6, has similar effects and is used in the same dosages, so they are considered as substitute drugs.
Ipamorelin represents the latest generation of GHRP. Unlike its predecessors GHRP-2 and GHRP-6, it does not cause the side effects of hunger and increased levels of the hormones prolactin and cortisol.
Group Growth Hormone Releasing Hormone (GHRH)
When using peptides of this group, an increase in growth hormone production is synchronized with a natural increase in growth hormone secretion (for example, at night), at other times of the day, an increase in hormone production as a result of taking the drug will be insignificant. In other words, these peptides enhance growth hormone secretion without disturbing the natural undulating curve.
This group includes:
GRF(1-29) Sermorelin
It is the safest peptide of all GHRHs. Even if the dosage is exceeded by two or more times, this drug still remains a safe remedy. Sermorelin has the following properties:
- increases muscle mass;
- reduces the layer of fat;
- improves the connective qualities of bone tissue;
- strengthens the immune system;
- improves the functioning of the cardiovascular system.
Sermorelin is often combined with ipamorelin. Their combined use has established itself as one of the best peptide courses. It is not as powerful as the CJC-1295 + GHRP-6 course, but, as stated, its main advantage is in safety. In the US, sermorelin is prescribed even for children.
COURSES FOR MASS
Course #1: For Beginners
GHRP or Hexarelin
Here you will need to put 100-200 mcg of the substance 3 times a day. Inexpensive and effective course.
Note: You need to inject after eating after 40-60 minutes, after the injection, do not eat carbohydrates and fats, ideally do not eat anything. After 40 minutes, the release of GH begins to decline and you can eat. Proteins prolong release, especially glutamine, arginine, D-Aspartic Acid.
For a course of 2 months you will need: 10 vials of GHRP (2 or 6)
Course cost: 2600 rubles.
Course number 2: To gain muscle mass and strength
We put 100 mcg of each preparation 3 times a day one hour before and after meals. In 90 percent of cases, these drugs increase appetite well, so you can score well on this course. These peptides can be used together to achieve a synergistic effect. In studies, the maximum concentrations of growth hormone in the blood were observed with the joint administration of GHRP-6 and GHRP-2.
It is worth noting that this course, despite its effectiveness, is not expensive enough.
For a course of 1 month you will need: 3 bottles of GHRP2 and 3 bottles of GHRP6
The cost of the course is 2600 rubles.
Course number 3: Mass and extreme muscle growth
GHRP2(6) + CJC1295 DAC
It has been proven and well established that the simultaneous administration of GHRH and CJC-1295 dac results in a synergistic effect. These peptides have a potentiating effect on each other. In other words, with the introduction of one CJC-1295, we will get a stimulating effect of 4 points. With the introduction of GHRP-6 alone, we get an effect of 2 points. With the introduction of both substances at the same time, we will get an effect not of 6 points (additive effect 2 + 4 = 6), as one might expect, but of 10 points - more than the sum of each separately (potentiating effect 2 + 4 = 10). Thus, we not only get a greater anabolic response, but we can also save money.
Total, course for 1 month - 3 vials GHRP 2 or 6 + CJC 1295 DAC 4 vials
The cost of the course is 3540 rubles.
Course number 4 On a qualitative set of muscle mass
PEG MGF + GHRP
An excellent course, allows you to gain significant volumes of high-quality muscle mass.
We put Peg MGF on training days at 200mcg in one shot and put it directly into the fat fold like any other peptides. GHRP-6 put in the morning and evening at 200 mcg
A course option for 1 month is possible, the results will be visible, but this peptide tends to gain momentum over time, then a course of 2 months is still recommended, and 3 is possible.
For a course of 1 month you will need: 2 bottles of Peg-MGF + 3 bottles of GHRP
The cost of the course is 2080 rubles.
Course No. 5 The most powerful dew hormone booster
GHRP2 + CJC1295+ PEG MGF
A set of muscle mass (better than in other combinations), an improvement in strength indicators and other properties inherent in the drugs listed above will be felt significantly noticeably after using this combination.
For a course of 1 month you will need: 2 bottles of Peg-MGF + 3 bottles of GHRP + 4 bottles of CJC DAC
The cost of the course is 4840 rubles.
Course number 6 Manifestation of venousness and quality of muculature + increase in strength
hexarelin+ cjc1295
This course consists of two peptides namely, hexarelin and szhs1295. The course is 1 month long. If your weight is 80-90 kg, then the dosages of the peptides are 100 mcg of hexarelin three times a day and cjc1295 DAC twice a week.
During this course of peptides, you must adhere to balanced diet and active physical activity. Protein intake should be increased.
For a course of 1 month you will need: 6 bottles of HEXARELIN + 4 bottles of CJC DAC
The cost of the course is 4500 rubles.
Course No. 7 For those who do not have the opportunity to frequently inject
CJC1295 DAC+ PEG MGF
This bundle is good for those who do not want to do frequent injections. CJC1295 DAC 2 times a week, 1000 mcg at a time. And PEG MGF 200 mcg once a day of training.
For 1 month you will need: 4 bottles of CJC1295 DAC and 2 bottles of PEG MGF
The cost of the course is 4060 rubles.
A course for strength
Course number 1: For strength and endurance, for the treatment of ligaments and joints. Muscle growth and recovery.
TB-500
First week, loading dose, 10 mg (2 vials per week),
- next 5 weeks 5 mg per week (2 vials per week)
- and the rest of the week it is a maintenance dose of 10 mg per month (2 mg per week), this scheme is the most optimal and effective.
Result: improvement of speed-strength indicators, health-improving effect on the heart.
It will take 7 bottles of TB-500 for the first 6 weeks and then 2 bottles per month to maintain the effect.
Drying courses
Course number 1: Local fat burning
HGH Frag 176-191
Peptide is a fat burner. In terms of its effectiveness, it is the number one drug in the world. Has no side effects!
HGH Frag (176-191) is a stabilized fragment of the growth hormone molecule from amino acids 176 to 191. This peptide stimulates lipolysis (fat burning) 12 times more powerful than growth hormone and inhibits the formation of new fat. HGH Frag (176-191) is significantly cheaper than GH. It is one of the most promising drugs for the treatment of obesity.
Daily dose = 500-1000 mcg. It is divided into 3 doses. Best taken on an empty stomach.
For 1 month you will need: 10 vials.
The cost of the course is 3000 rubles.
Course No. 2 Drying + improvement of relief and muscle density
hgh176-191 + cjc1295 DAC
This course consists of the use of two peptides, namely hgh176-191 and cjc1295. Peptide hgh176-191 is engaged in burning fat, helps a person get rid of excess weight, at the same time, the cjc1295 peptide - enhances the action of its partner, and also makes the muscles firmer and stronger.
This course should be accompanied by diet and exercise. Without these components, the result will be low.
The cost is calculated based on your weight, in order to buy a course of peptides, please contact me
Peptides are used in bodybuilding to gain muscle volume, relief and strength for an athlete. They are on the menu as sports supplements and serve to get rid of excess weight, as well as speed dial required muscle mass.
In this case, it is worth distinguishing:
- activation of growth hormone;
- stimulation of muscle building;
- fat burning;
- increase in the speed of ongoing metabolic processes;
- increased immunity;
- strengthening of bone and cartilage tissues;
- body rejuvenation;
- reduction of the period of time for recovery of the body after hard training.
Many peptides in bodybuilding improve the sleep of athletes, increase their muscle tone, heal the skin, and even have a healing effect on microtraumas and wounds.
If in bodybuilding we compare the action of peptides in tablets with proteins, then in the first case their absorption by the body proceeds much faster and much easier.
Characteristics and types of peptides
There are structural and functional peptides.
Structural
Such peptides in tablets used in bodybuilding begin to act only after their complete breakdown into the corresponding amino acids. After that, they proceed to protein synthesis, which in turn contributes to the formation of muscle fibers. Among the most popular are the concentrate whey protein waterproofing.
It is these peptides in bodybuilding tablets that are specific building material. They also create the necessary conditions for nourishing the body with nutrients and creating conditions for anabolism. This is what leads to the growth of muscle mass, as well as to its preservation in the gained volume during the fasting period.
However, before taking such drugs, it is necessary to remember some of them. side effects: the possibility of protein poisoning and the advance of muscle development relative to the development of the ligaments themselves.
Functional
Uses them in bodybuilding to reduce unnecessary weight and build the required muscle mass in a short period of time. Such drugs begin to act immediately after the tablets have entered the athlete's body. They also increase the secretion of growth hormone compared to the normal state of the body.
Among positive effects distinguish:
- strengthening immune system;
- improving the condition of the ligaments in a bodybuilder.
In this case, the side effects are solely in the unpredictability of such drugs.
Taking these drugs
It cannot be said that bodybuilding is a sport that cannot do without peptides. However, they make it much easier to achieve your goals. For correct reception peptides, there are specially designed courses. Therefore, if the training is accompanied by taking the necessary peptides in tablets, then you can quickly achieve the desired results.
A course that promotes an increase in strength and body mass
It involves taking drugs such as GHRP6 and GHRP2 together. They must be taken for two months three times a day, one hour before or after meals, 150 or 200 mcg.
It is worth noting that the drugs significantly increase appetite, which contributes to the recruitment of the required body weight.
Extreme Muscle Building Course
In this case, a sport such as bodybuilding requires a different scheme, which consists of taking the peptides GHRP6, GHRP2 and MGF peg. Reception should be carried out three times a day, one hour before meals or after it. The dosage of the first two peptides should be between 150 and 200 micrograms, and the third is injected subcutaneously two hours (or just an hour) before the start of the workout.
A course that promotes endurance and weight gain
Bodybuilding has always been famous for its grueling workouts, and this attracts many athletes. However, not everyone is able to endure this kind of rhythm of classes. Therefore, there is a specially created course for the use of peptides that simplify this condition. We are talking about the use of the drug in tablets called TV-500. For three months, you need to use 23 bottles.
A course that promotes the development of strength and mass gain
It is designed for the use of GHRP2 peptides. This is not about pills, but injections, which must be taken exactly four per day, 200 or 250 mcg each. The course is calculated for two months. As a rule, bodybuilding does not tolerate cheapness, but in this case the option is acceptable.
A very powerful compound used by bodybuilding athletes is CJC-1295 and Hexarelin. However, this combination in bodybuilding has one serious by-effect: for two weeks in the body of an athlete, the sensitivity threshold is significantly underestimated.
The drug can be produced both in vials and tablets. For bodybuilding, both options are acceptable. In particular, Hexarelin without increasing appetite helps to increase and build new muscle mass. In addition to all of the above, it also improves general condition an athlete practicing bodybuilding, namely:
- significantly reduces the thickness of the fatty layer;
- perfectly heals microtraumas and wounds acquired during training;
- prevents premature wear of the joints.
Peptides: harm or benefit?
Any athlete, professional or amateur, who has been practicing bodybuilding for a long time will confidently say that working on creating relief and building muscle mass is a long and laborious, even exhausting process. And the point here is not only to build your workouts on integrated approaches or eat right. To increase the working body weight, peptides are needed that make up a specific part sports nutrition. After all, it is peptides in bodybuilding that support the body during incredible physical exertion and act “correctly” at the hormonal level.
Today, both in professional and amateur sports, peptides in tablets have taken a dominant place, as they allow the athlete to achieve the desired result with much less effort and in an incredibly short period of time.
With the help of special hormones, not only endurance and strength increase, but also the rate of gaining useful body weight rises to a new level.
Considering such quick results and positive achievements, one involuntarily begs the question, are peptides as safe as sports nutrition sellers assure us? What harm, besides benefit, do they bring to the human body? We will try to give a reasoned answer to these questions.
It should be noted right away that peptides are not hormonal agents, and their intake is not an interference with a separate republic of the body - a hormonal system that lives by its own rules and laws and does not tolerate “foreigners”. Therefore, their effect on the athlete's body cannot be detrimental in comparison with hormonal drugs.
From the foregoing, it must be concluded that peptides are not capable of harming the athlete's body, since they are organic compounds consisting exclusively of a group of amino acids. Summing up what has been said, we remind you once again that only hormonal drugs are harmful to a bodybuilder.
The intake of foreign hormonal agents can provoke a complete stop in the body's production of its own hormones, based on the fact that it receives them from the outside. It will never be possible to resume this process, and the athlete will be forced to take artificial preparations containing the hormones necessary for his life until the end of his days.
Relief muscles are the dream of not only bodybuilders, but also people who want to have a moderately muscular body. The combination of sports and diet - great way get the desired shape. It is believed that you can do this much faster by using peptides for muscle growth. Does it make sense to start using them and how harmless is it?
A group of certain substances that form proteins in the body and are connected by a peptide bond that unites amino acids different groups are called peptides. This is an artificially synthesized product that is used in pharmacology, medicine and cosmetology.
As you know, hormones are needed to increase muscle mass. However, their use can unpredictably change the hormonal background and lead to atrophy of the endocrine glands. With regard to peptides, it is safe to say that their use does not give such a “reverse loop” effect. They are easier to digest, and the result is much more noticeable:
- splitting in the body, help to synthesize protein;
- inhibit muscle breakdown;
- reduce the layer of fat;
- provide a rejuvenating effect;
- stimulate the regeneration of cells of all organs;
- promote bone growth;
- strengthen the immune system.
There are several groups of peptide drugs that affect the body in different ways. In particular, these are:
- Ghrelin group. The active substance provokes a peak in the accumulation of growth hormone immediately after ingestion. This type includes GHRP-2 (stimulates the pituitary gland and appetite) GHRP-6 (does not increase appetite), Hexarelin (identical to GHRP-6), Ipamorelin (does not cause an increase in hormonal levels, in particular, an increase in prolactin and steroid hormones) .
- group Releasing growth hormone peptides. The action of these drugs is based on an increase in the synthesis of growth hormone, but synchronously with the natural process in the body.
Ghrelin group, as a rule, is used in different combinations, which allows you to achieve a more noticeable result.
It would seem that the use of these drugs gives those who dream of impressive muscles how much useful! However, in their case, not everything is so simple. Let's look at both sides of the coin.
Host Opinions
If we turn to discussions on the forums of the advantages and disadvantages of using peptides, then it will be much more difficult to find negative reviews from those who took them. And this state of affairs is explained by the fact that peptides:
- economically more profitable, because they are significantly cheaper;
- have a short decay time, so it is almost impossible to detect peptides on doping control;
- make it possible to adjust the amount of growth hormone, which is necessary to obtain the desired result;
- do not lead to atrophy of the internal secretion system.
But most importantly, judging by the reviews, they work! With the combination of GHRP-2 and GHRP-6, noticeable muscle growth is observed, while there is no inhibition of sexual function, as can occur as a result of the use of steroid drugs. In addition, weight gain is inhibited due to overeating.
Reviews of doctors
The main argument of experts in favor of moderate rather than widespread use of peptides is based on the fact that the effect of these drugs has not yet been fully studied. From this, logically, it follows that it is impossible to reliably predict the consequences of their intake, adverse reactions. Therefore, doctors' reviews of peptides are usually negative. In their opinion:
- it is difficult to choose the optimal drug;
- the negative consequences of the use may not appear now, but after a few years.
?
Powdered peptides are packaged in 2 or 5 ml vials. 2 ml of water for injection is added to this container - this amount of liquid allows you to obtain the optimal concentration of the substance. Here ground rules related to its use:
- injections should be done in the fatty layer;
- the distance between the injection sites of the syringe should be at least 3 cm;
- the concentration can increase, but 2-3 g per kilogram of weight is the limit;
- the angle of the syringe to the body - 45 degrees;
- 2 hours before and 40 minutes after the injection procedure, you can not eat;
- between injections should take about a day;
- you need to store the substance in the refrigerator, no more than 7-10 days;
- limit yourself to simple carbohydrates.
Peptides for muscle growth are new generation products that allow you to bring your body parameters closer to the ancient models of courageous handsome men. However, when deciding on their use, one should take into account the difference in opinions of patients and doctors. If the former evaluate (and highly appreciate) the immediate result, then doctors emphasize that the consequences of using peptides have not yet been fully studied, which means that they can be negative.
