Author: Vkopirait
Peptides are a sequence of amino acids connected by amide (peptide) bonds. They produce polypeptides (from a variety of more than 100 amino acids), oligopeptides (no more than 50-100) and simple peptides(up to 10 amino acids). From the position of a peptide, an amino acid is a monomer unit, or simply a monomer. The limiting case of a peptide - a protein - is a chain of amino acids that includes over 6000 monomers. This classification is conditional. From the point of view of a practicing bodybuilder, it is important to divide peptides into those that contribute to the set muscle mass, and those that lead to weight loss (increased fat burning). Most of them have both effects simultaneously, but with different effects. The subject of this article will be peptides for gaining muscle mass:
- GHRP-6 (hexarelin, HEX)- stimulator of growth hormone secretion (somatotropin). Developed for the treatment of diseases caused or accompanied by a deficiency of this hormone. Does not increase appetite or increase the production of cortisol and prolactin. When GHRP-6 and GHRP-2 are used simultaneously, a synergistic effect is observed. The peptide is used by many athletes to increase endurance during training and to gain more definition. appearance. The action is directed directly to the pituitary gland. In addition to the secretion of growth hormone, the production of insulin-like growth factor (IGF-1) is stimulated. A side effect is increased burning subcutaneous fat, reducing recovery time after training, etc.
- GHRP-2- another somatotropin-releasing peptide, classified as an oligopeptide and recognized as one of the most powerful stimulators of growth hormone. Side effects include the production of cortisol and prolactin, as well as increased appetite. It acts directly on the pituitary gland, stimulating it to produce somatotropin in quantities exceeding the “normal state” by 7-15 times (in terms of effectiveness, this makes GHRP-2 similar to a direct injection of somatotropin). The action of the peptide affects the hypothalamus and activates ghrelin receptors (this explains the increased appetite). It is believed that combined use with GHRP-6 eliminates these disadvantages
- ipamorelin- a peptide that enhances the secretion of growth hormone, belongs to the latest generation of drugs for stimulating the production of somatotropin. Directly enhances the production of growth hormone and also suppresses the effect of somatostatin (a hormone that inhibits the secretion of somatotropin). Does not provoke the onset or increase in feelings of hunger, does not lead to the production of cortisol and prolactin (the first is a catabolic hormone that destroys muscle tissue and large quantities formed in the body after physical activity, and the second provokes the manifestation of such effects as gynecomastia, decreased libido)
- GRF(1-29), sermorelin - like the peptides listed above, sets a “program” for the peak production of growth hormone (after which its production is restored to its original values). Taking the drug is an alternative to growth hormone therapy. A synergistic effect is observed when using GFR(1-29), GHRP-6, GHRP-2 and ipamorelin together
- CJC-1295- a peptide, identical in action to somatoliberin, enhances the production of somatotropin. Somatoliberin is two peptides, one of 40 amino acids, and the second of 44, acting directly on the pituitary gland (the pituitary gland is responsible for the synthesis of somatotropin)
- gonadorelin- a stimulator of luteinizing hormone secretion (which in turn provokes leidigo cells to produce testosterone). A drug based on gonadorelin is developed as a replacement for synthetic testosterone. Gonadorelin, through increased production of follicle-stimulating hormone, improves the functioning of the testicles, which also helps to increase the secretion of testosterone (while aromatization - the conversion of testosterone into extradiol - does not go beyond the “norm”). Side effects: normalization of sexual function
- PEG MGF, pegylated mechanical growth factor - stimulates the processes of division of myoblasts and satellite cells muscle tissue, precursors of muscle fiber (triggering hyperplasia). Affects various muscle cell receptors. MGF itself has a short half-life (only a few minutes), PEGylation serves the purpose of stabilizing the drug. Side effects of mechanical growth factor are acceleration of recovery after physical activity and increasing endurance during training
- oxytocin- hypothalamic hormone, peptide. Helps maintain muscle mass by suppressing cortisol secretion
- glucagon- increases the availability of basic energy sources, helping to increase the duration and intensity of training. Enhances the secretion of catelochamines, which stimulate the pituitary gland and hypothalamus. The presence of catelochamines is a necessary condition for the body's adaptation to physical activity.
Peptides, unlike synthetic hormones (somatotropin, insulin-like growth factor and testosterone), have no negative side effects in the form of gynecomastia, inhibition of testicular activity, aromatization of testosterone. Their action is aimed at stimulating the body’s internal resources for the production of androgenic anabolic hormones. Distinctive feature- It is impossible to say with certainty how much growth hormone, testosterone or IGF-1 will be produced in response to the use of a given amount of a particular drug.
The indirect effects of peptides on gaining muscle mass include:
- strengthening ligaments and preventing their damage and diseases. Healthy strong ligaments are an opportunity to work with large and large scales, which has a beneficial effect on muscle growth
- acceleration of healing of microtraumas and damage to muscle tissue (this property is especially pronounced in hexarelin)
- stimulating the work of the pituitary gland, in particular, overcoming the inhibition of the body’s own ability to synthesize somatotropin (usually caused by abuse using synthetic sources of growth hormone)
- improvement in the condition of bone tissue - bones grow along with muscle mass (they become denser), which is a necessary condition for continuing to increase muscle volume (bone strength is one of the limitations in gaining body weight)
- strengthening the immune system - fewer missed workouts due to illnesses, fewer illnesses themselves, when the body is forced to mobilize all resources to suppress infection, bacteria, viruses, removing them from anabolic and anti-catabolic processes
- normalization of sleep (for example, CJC-1295).
Currently, science knows over 1,500 peptides. Most of them are synthesized. Experts note an increased need for the supply of peptides from the outside for the following categories of people: patients (with impaired pituitary gland function), children and adolescents, the elderly, athletes.
To have a beautiful, harmonious developed body, an integrated approach is required. For bodybuilders, this is not only correct organized training and a balanced diet, but also special supplements.
Hormones play a major role in stimulating muscle growth and increasing the body's endurance, but taking them is not always harmless.
With an excess of hormones, when they come from outside, the body's own glands can stop producing them and atrophy.
In bodybuilding, peptides are used as effective analogs of hormonal anabolics.
They promote the restoration of cells and various tissues of the body, including muscle fibers.
Why "peptides"?
Peptides– organic compounds consisting of a sequence of amino acids linked together by a peptide bond. Currently, they are well studied, are a product of artificial synthesis and are widely used in medicine, pharmacology, and cosmetology.
From the point of view of benefits for bodybuilding, peptides are usually divided into structural and functional.
- Structural peptides are broken down in the body to their basics, and then their own protein is synthesized from the resulting amino acids. Compared to simple proteins, peptides are absorbed by the body easier and faster. Structural peptides enrich the body with appropriate amino acids, stimulate anabolism, but have some side effects: protein poisoning is possible, the development and growth of muscles when taken is ahead of the development of ligaments.
- Functional peptides are absorbed by the body in the original form in which they enter it. They can be roughly divided into means for muscle growth and means for weight loss. Most of them simultaneously have both effects. When discussing the role of peptides in bodybuilding, they usually refer to functional compounds. They stimulate the production of growth hormone and testosterone hormone, accelerate metabolism, activate muscle growth, and strengthen ligaments. However, their side effects lies in the unpredictability of the effect. The same dosage can give completely different effects in different athletes. The increase in growth hormone secretion can vary from twofold to sevenfold and even 15fold. It is also possible that the peptide will not be absorbed at all and will simply be excreted from the body.
However, peptides have a number of advantages over artificial growth hormones.
Advantages of peptides over growth hormones
Currently, peptides whose action is aimed at stimulating the secretion of growth hormone have become widely popular.
Popular peptides
Among the popular peptides the following groups can be distinguished:
Ghrelin group (GHRP)
The main feature of drugs in this group is that an increase in the level and peak concentration of growth hormone is observed immediately after administration, regardless of the time of day and the presence of the hormone somatostatin in the blood.
This group includes:
- GHRP-2
- GHRP-6 and Hexarelin
- Ipamorelin
is able to penetrate the body through the mucous membrane of the oral cavity, which avoids injections, and enters the bloodstream, bypassing the liver. Its main effects:
GHRP-6 similar in properties and effects to GHRP-2, although it is inferior to it in the effectiveness of stimulating growth hormone. Their main difference is that GHRP-6 has less of an effect on appetite. These two peptides can be used together to achieve a synergistic effect.
When they are administered together, the maximum concentration of growth hormone in the blood is recorded.
Hexarelin is a structural analogue of GHRP-6, has similar effects and is used in the same dosages, so they are considered as substitute drugs.
Ipamorelin represents the latest generation of GHRP. Unlike its predecessors GHRP-2 and GHRP-6, it does not cause the side effects of hunger and increased levels of the hormones prolactin and cortisol.
Group Growth hormone releasing hormone (GHRH)
When using peptides of this group, the increase in the production of growth hormone is synchronized with the natural increase in the secretion of growth hormone (for example, at night); at other times of the day, the increase in hormone production as a result of taking the drug will be insignificant. In other words, these peptides enhance the secretion of growth hormone without disrupting the natural wave-like curve.
This group includes:
GRF(1-29) Sermorelin
It is the safest of all GHRH peptides. Even if the dosage is doubled or more, this drug still remains a safe remedy. Sermorelin has the following properties:
- increases muscle mass;
- reduces the layer of fat;
- improves the connective qualities of bone tissue;
- strengthens the immune system;
- improves the functioning of the cardiovascular system.
Sermorelin is often combined with ipamorelin. Their combined use has established itself as one of the best peptide courses. It is not as powerful as the CJC-1295 + GHRP-6 course, but, as stated, its main advantage is safety. In the USA, sermorelin is prescribed even to children.
COURSES FOR MASS
Course No. 1: For beginners
GHRP or Hexarelin
Here you will need to take 100-200 mcg of the substance 3 times a day. Inexpensive and effective course.
Note: You need to give the injection after a meal, 40-60 minutes later, after the injection, do not eat carbohydrates and fats, ideally, do not eat anything. After 40 minutes, the release of GH begins to decline and you can eat. Proteins prolong the release, especially glutamine, arginine, D-Aspartic Acid.
For a 2 month course you will need: 10 bottles of GHRP (2 or 6)
Course cost: 2600 rub.
Course No. 2: Gaining muscle mass and strength
We take 100 mcg of each drug 3 times a day, an hour before and after meals. In 90 percent of cases, these drugs improve appetite well, so you can gain quite a lot on this course. These peptides can be used together to achieve a synergistic effect. In studies, the maximum concentrations of growth hormone in the blood were observed with the combined administration of GHRP-6 and GHRP-2.
It is worth noting that this course, while effective, is quite inexpensive.
For a 1 month course you will need: 3 bottles of GHRP2 and 3 bottles of GHRP6
The cost of the course is 2600 rubles.
Course No. 3: Mass and extreme muscle growth
GHRP2(6) + CJC1295 DAC
It has been proven and clearly established that the simultaneous administration of GHRH and CJC-1295 dac leads to a synergistic effect. These peptides have a potentiating effect on each other. In other words, with the introduction of one CJC-1295 we will get a stimulating effect of 4 points. When introducing GHRP-6 alone, we get an effect of 2 points. When both substances are administered simultaneously, we will get an effect not of 6 points (additive effect 2+4=6), as one might expect, but of 10 points - more than the sum of each separately (potentiating effect 2+4=10). This way we not only get a greater anabolic response, but we can also save money.
Total, course for 1 month - 3 bottles GHRP 2 or 6 + CJC 1295 DAC 4 bottles
The cost of the course is 3540 rubles.
Course No. 4 For high-quality muscle mass gain
PEG MGF + GHRP
An excellent course that allows you to gain significant amounts of high-quality muscle mass.
We put Peg MGF on training days at 200 mcg in one injection and put it directly into the fat fold like any other peptides. GHRP-6 is given in the morning and evening at 200 mcg
A course option of 1 month is possible, the results will be visible, but this peptide tends to gain momentum over time, then a course of 2 months is still recommended, or 3 is possible.
For a 1 month course you will need: 2 bottles of Peg-MGF + 3 bottles of GHRP
The cost of the course is 2080 rubles.
Course No. 5 The most powerful dew hormone booster
GHRP2 + CJC1295+ PEG MGF
Gaining muscle mass (better quality than in other combinations), improving strength performance and other properties inherent in the drugs listed above will be felt significantly after using this combination.
For a course of 1 month you will need: 2 bottles of Peg-MGF + 3 bottles of GHRP + 4 bottles of CJC DAC
The cost of the course is 4840 rubles.
Course No. 6 Manifestation of venousness and quality of muscle tissue + increase in strength
hexarelin+ cjc1295
This course consists of two peptides, namely, hexarelin and szhs1295. The course length is 1 month. If your weight is 80-90 kg, then the peptide dosages are 100 mcg of hexarelin three times a day and cjc1295 DAC twice a week.
During this course of peptides, you must adhere to balanced diet and active physical activity. Protein intake should be increased.
For a 1 month course you will need: 6 bottles of HEXARELIN + 4 bottles of CJC DAC
The cost of the course is 4500 rubles.
Course No. 7 For those who do not have the opportunity to give frequent injections
CJC1295 DAC+ PEG MGF
This bundle is good for those who do not want to make frequent injections. CJC1295 DAC is administered 2 times a week, 1000 mcg at a time. And PEG MGF 200 mcg once on training days.
For 1 month you will need: 4 bottles of CJC1295 DAC and 2 bottles of PEG MGF
The cost of the course is 4060 rubles.
Course for strength
Course No. 1: For strength and endurance, for the treatment of ligaments and joints. Muscle growth and recovery.
TB-500
First week, loading dose, 10 mg (2 bottles per week),
- next 5 weeks 5 mg per week (2 bottles per week)
- and the remaining weeks are a maintenance dose of 10 mg per month (2 mg per week), this regimen is the most optimal and effective.
Result: improvement in speed and strength indicators, healing effect on the heart.
You will need 7 bottles of TB-500 for the first 6 weeks and then 2 bottles per month to maintain the effect.
Drying courses
Course No. 1: Local fat burning
HGH Frag 176-191
Peptide is a fat burner. In terms of its effectiveness, it is the number one drug in the world. Has no side effects!
HGH Frag (176-191) is a stabilized fragment of the growth hormone molecule from amino acids 176 to 191. This peptide stimulates lipolysis (fat burning) 12 times more powerful than growth hormone and suppresses the formation of new fat. HGH Frag (176-191) is much cheaper than GH. It is one of the most promising drugs for the treatment of obesity.
Daily dose = 500-1000 mcg. It is divided into 3 steps. It is best to take it on an empty stomach.
For 1 month you will need: 10 bottles.
The cost of the course is 3000 rubles.
Course No. 2 Drying + improvement of muscle relief and density
hgh176-191 + cjc1295 DAC
This course consists of the use of two peptides, namely hgh176-191 and cjc1295. The hgh176-191 peptide burns fat and helps a person get rid of excess weight, at the same time, the cjc1295 peptide enhances the effect of its partner, and also makes the muscles more solid, textured and strong.
This course must be accompanied by diet and training. Without these components, the result will be low.
The cost is calculated based on your weight, to buy a course of peptides please contact me
To gain muscle volume, relief and strength for an athlete, peptides are used in bodybuilding. They are on the menu as sports supplements and serve to get rid of excess weight, as well as speed dial required muscle mass.
In this case, it is worth distinguishing:
- activation of growth hormone;
- stimulating muscle building;
- burning fat;
- increasing the speed of ongoing metabolic processes;
- increasing immunity;
- strengthening bone and cartilage tissue;
- rejuvenation of the body;
- reducing the period of time for the body to recover after hard training.
Many peptides in bodybuilding improve athletes' sleep, increase muscle tone, improve skin health, and even have a healing effect on microtraumas and wounds.
If in bodybuilding we compare the effect of peptides in tablets with proteins, then in the first case their absorption by the body is much faster and much easier.
Characteristics and types of peptides
There are structural and functional peptides.
Structural
Such peptides in tablets used in bodybuilding begin to act only after they are completely broken down into the corresponding amino acids. After which they begin protein synthesis, which in turn promotes the formation of muscle fibers. Among the most popular is concentrate whey protein waterproofing
It is these peptides in bodybuilding tablets that are specific building material. They also create the necessary conditions for feeding the body with nutrients and creating conditions for anabolism. This is what leads to the growth of muscle mass, as well as its preservation in the accumulated volume during the fasting period.
However, before taking such drugs, you need to remember some of them side effects: the possibility of protein poisoning and the advance of muscle development relative to the development of the ligaments themselves.
Functional
Bodybuilding uses them to reduce unnecessary weight and build the required muscle mass in a short period of time. Such drugs begin to act immediately after the tablets enter the athlete’s body. They also increase the secretion of growth hormone compared to the body's normal state.
Among positive effects distinguish:
- strengthening immune system;
- improving the condition of the bodybuilder’s ligaments.
In this case, the side effects lie solely in the unpredictability of such drugs.
Taking these medications
It cannot be said that bodybuilding is a sport that cannot do without peptides. However, they make achieving your goals much easier. For correct intake There are specially designed courses for peptides. Therefore, if you accompany your workout by taking the necessary peptides in tablets, you can quickly achieve the desired results.
A course that helps increase strength and body weight
It involves taking drugs such as GHRP6 and GHRP2 together. They must be taken for two months three times a day, an hour before or after meals, 150 or 200 mcg.
It is worth noting that the drugs significantly increase appetite, which contributes to gaining the necessary body weight.
Extreme muscle building course
In this case, a sport such as bodybuilding requires a different regimen, which consists of taking GHRP6, GHRP2 and MGF peg peptides. The dose should be taken three times a day, one hour before or after meals. The dosage of the first two peptides should be from 150 to 200 mcg, and the third is administered subcutaneously two hours (or just an hour) before the start of training.
A course that helps increase endurance and increase body weight
Bodybuilding has always been famous for its grueling workouts, and this attracts many athletes. However, not everyone is able to endure this kind of rhythm of classes. Therefore, there is a specially created course of using peptides that simplify this condition. We are talking about the use of a drug in tablets called TV-500. Over the course of three months, you need to consume 23 bottles.
A course that promotes strength development and mass gain
It is designed for the use of GHRP2 peptides. We are not talking about tablets, but injections, which must be taken exactly four times a day, 200 or 250 mcg each. The course is designed for two months. As a rule, bodybuilding does not tolerate cheapness, but in this case the option is acceptable.
A very powerful compound that is used by bodybuilding athletes is CJC-1295 and Hexarelin. However, this combination in bodybuilding has one serious side effect: over the course of two weeks, the threshold of sensitivity in the athlete’s body is significantly reduced.
The drug can be produced both in bottles and tablets. For bodybuilding, both options are acceptable. In particular, Hexarelin helps increase and build new muscle mass without increasing appetite. In addition to all that has been said, it also helps to improve general condition an athlete practicing bodybuilding, namely:
- significantly reduces the thickness of the fat layer;
- perfectly heals microtraumas and wounds acquired during exercise;
- prevents premature wear of joints.
Peptides: harm or benefit?
Any athlete, professional or amateur, who has been practicing bodybuilding for a long time, will confidently say that working on creating relief and building muscle mass is a long and labor-intensive, even grueling process. And the point here is not only to build your training around integrated approaches or eat right. To increase working body weight, peptides that make up a specific part are necessary sports nutrition. After all, it is peptides in bodybuilding that support the body during periods of incredible physical activity and act “correctly” at the hormonal level.
Today, in both professional and amateur sports, peptides in tablets have taken a leading place, as they provide the athlete with the opportunity to achieve the desired result with much less effort and in an incredibly short period of time.
With the help of special hormones, not only does endurance and strength increase, but also the rate of gain of useful body weight rises to a new level.
Considering such quick results and positive achievements, the question inevitably arises: are peptides as safe as sports nutrition sellers assure us? What harm, besides the benefit, do they bring to the human body? We will try to give a reasoned answer to these questions.
It is immediately worth noting that peptides are not hormonal agents, and their use does not constitute an intervention in a separate republic of the body - the hormonal system, which lives by its own rules and laws and does not tolerate “foreigners.” Therefore, their effect on the athlete’s body cannot be destructive in comparison with hormonal drugs.
From the above, it is necessary to conclude that peptides are not capable of harming the athlete’s body, since they are organic compounds consisting exclusively of a group of amino acids. To summarize what has been said, we remind you once again that only hormonal drugs cause harm to a bodybuilder.
Taking foreign hormonal drugs can provoke a complete stop in the body's production of its own hormones, based on the fact that it receives them from the outside. It will never be possible to resume this process, and the athlete will be forced to take artificial drugs containing hormones necessary for his life until the end of his days.
Defined muscles are the dream of not only bodybuilders, but also people who want to have a moderately muscular body. The combination of sports and diet - great way acquire the desired shapes. It is believed that you can do this much faster by using peptides for muscle growth. Does it make sense to start using them and how harmless is it?
A group of specific substances that form proteins in the body and that are connected by a peptide bond that joins amino acids different groups, are called peptides. This is an artificially synthesized product that is used in pharmacology, medicine and cosmetology.
As you know, hormones are needed to increase muscle mass. However, their use can unpredictably change hormonal levels and lead to atrophy of the endocrine glands. Regarding peptides, we can say with confidence that their use does not give such a “reverse loop” effect. They are easier to digest, and the results are much more noticeable:
- when broken down in the body, they help synthesize protein;
- inhibit muscle destruction;
- reduce the layer of fat;
- provide a rejuvenating effect;
- stimulate cell regeneration of all organs;
- promote bone growth;
- strengthen the immune system.
There are several groups of peptide drugs that have different effects on the body. In particular, these are:
- Ghrelin group. The active substance provokes a peak in the accumulation of growth hormone immediately after entering the body. This type includes GHRP-2 (stimulates the pituitary gland and appetite), GHRP-6 (does not cause an increase in appetite), Hexarelin (identical to GHRP-6), Ipamorelin (does not cause an increase in hormonal levels, in particular, an increase in prolactin and steroid hormones) .
- group Releasing growth hormone peptides. The action of these drugs is based on increasing the synthesis of growth hormone, but synchronously with the natural process in the body.
The Ghrelin group is usually used in different combinations, which allows you to achieve a more noticeable result.
It would seem how much benefit the use of these drugs gives to those who dream of impressive muscles! However, in their case, not everything is so simple. Let's look at both sides of the coin.
Opinions of those receiving
If you look at discussions on forums about the advantages and disadvantages of using peptides, it will be much more difficult to find negative reviews from users. And this state of affairs is explained by the fact that peptides:
- more economically profitable, because they are significantly cheaper;
- have a short decay period, so it is almost impossible to detect peptides during doping control;
- make it possible to regulate the amount of growth hormone that is needed to obtain the desired result;
- do not lead to atrophy of the internal secretion system.
But most importantly, judging by the reviews, they work! With the combination of GHRP-2 and GHRP-6, noticeable muscle growth is observed, without suppression of sexual function, as can occur as a result of the use of steroid drugs. In addition, weight gain due to overeating is inhibited.
Reviews from doctors
The main argument of experts in favor of moderate rather than widespread use of peptides is based on the fact that the effect of these drugs has not yet been fully studied. From this, logically, it follows that it is impossible to reliably predict the consequences of taking them and adverse reactions. Therefore, doctors' reviews of peptides are usually negative. According to them:
- it is difficult to choose the optimal drug;
- the negative consequences of use may not appear now, but several years later.
?
Peptides in powder form are packaged in 2 or 5 ml bottles. 2 ml of water for injection is added to this container - this amount of liquid allows you to obtain the optimal concentration of the substance. Here basic rules related to its use:
- injections should be given into the fat layer;
- the distance between the syringe insertion points must be at least 3 cm;
- the concentration may increase, but 2-3 g per kilogram of weight is the limit;
- the angle of inclination of the syringe to the body is 45 degrees;
- You cannot eat 2 hours before and 40 minutes after the injection procedure;
- About a day should pass between injections;
- The substance should be stored in the refrigerator for no more than 7-10 days;
- You need to limit yourself to simple carbohydrates.
Peptides for muscle growth are a new generation of products that allow you to bring your body parameters closer to the ancient examples of courageous handsome men. However, when deciding to use them, one should also take into account the difference in opinions of patients and doctors. If the former evaluate (and highly value) the immediate result, then doctors emphasize that the consequences of using peptides have not yet been fully studied, which means they can be negative.
