Respiration is a complex of physiological processes that ensure the exchange of oxygen and carbon dioxide between the cells of the body and the external environment. It includes next steps:

1. External respiration or ventilation. This is the exchange of respiratory gases between atmospheric air and the alveoli.

2. Diffusion of gases in the lungs, i.e. their exchange between alveolar air and blood.

3. Transport of gases by blood.

4. Diffusion of gases in tissues. Exchange of gases between blood and intracellular fluid.

5. Cellular respiration. Oxygen uptake and carbon dioxide production in cells.

Mechanism of external respiration.

External respiration is carried out as a result of rhythmic movements of the chest. The respiratory cycle consists of phases of inhalation (inspiratio) and exhalation (exspiratio), between which there is no pause. At rest in an adult, the frequency respiratory movements 16-20 per minute. Inhalation is an active process. With a calm breath, the external intercostal and intercartilaginous muscles contract. They raise the ribs, and the sternum moves forward. This leads to an increase in the sagittal and frontal dimensions of the chest cavity. At the same time, the muscles of the diaphragm contract. Its dome descends, and the abdominal organs move down, to the sides and forward. Due to this, the chest cavity also increases in the vertical direction. After the end of inspiration, the respiratory muscles relax. The exhalation begins. Calm exhalation is a passive process. During it, the chest returns to its original state. This happens under the influence of its own weight, stretched ligamentous apparatus and pressure on the diaphragm of the abdominal organs. At physical activity, pathological conditions accompanied by shortness of breath (pulmonary tuberculosis, bronchial asthma etc.) forced breathing occurs. Auxiliary muscles are involved in the act of inhalation and exhalation. With forced inspiration, the sternocleidomastoid, scalene, pectoral, and trapezius muscles additionally contract. They contribute to the additional lifting of the ribs. During forced exhalation, the internal intercostal muscles contract, which increase the lowering of the ribs, i.e. it is an active process. There are thoracic and abdominal types of breathing. During the first breath, it is mainly carried out due to the intercostal muscles, during the second - due to the muscles of the diaphragm. Thoracic or costal type of breathing is typical for women. Abdominal or diaphragmatic - for men. Physiologically, the abdominal type is more beneficial, because. it is done with less energy. In addition, the movement of the abdominal organs during breathing prevents their inflammatory diseases. Sometimes there is a mixed type of breathing.

Despite the fact that the lungs are not fused with the chest wall, they repeat its movements. This is due to the fact that between them there is a closed pleural gap. From the inside, the wall of the chest cavity is covered with a parietal sheet of the pleura, and the lungs with its visceral sheet. There is a small amount of serous fluid in the interpleural fissure. When inhaling, the volume of the chest cavity increases, and since the pleural cavity is isolated from the atmosphere, the pressure in it decreases. The lungs expand, the pressure in the alveoli becomes lower than atmospheric pressure. Air enters the alveoli through the trachea and bronchi. During exhalation, the volume of the chest decreases. The pressure in the pleural space increases, the air comes out of the alveoli. The movements or excursions of the lungs are provided by fluctuations in the negative interpleural pressure. After a quiet exhalation, it is lower than atmospheric by 4-6 mm Hg. At the height of a quiet breath at 8-9 mm Hg. After forced exhalation, it is lower by 1-3 mm Hg, and after forced inspiration by 10-15 mm Hg. The presence of negative interpleural pressure is explained by the elastic recoil of the lungs. This is the force with which the lungs tend to shrink towards the roots, opposing atmospheric pressure. It is due to the elasticity of the lung tissue, which contains many elastic fibers. In addition, elastic traction increases the surface tension of the alveoli. From the inside they are covered with a film of surfactant. It is a lipoprotein produced by the mitochondria of the alveolar epithelium. Due to the special structure of its molecules, on inhalation it increases the surface tension of the alveoli, and on exhalation, when their size decreases, on the contrary, it decreases. This prevents the alveoli from collapsing, i.e. the occurrence of atelectasis. With a genetic pathology, the production of surfactant is disrupted in some newborns. Atelectasis occurs and the child dies. In old age, as well as in some chronic lung diseases, the number of elastic fibers increases. This phenomenon is called pneumofibrosis. Respiratory excursions are difficult. With emphysema, the elastic fibers, on the contrary, are destroyed, and the elastic recoil of the lungs decreases. The alveoli swell, the amount of lung excursion also decreases. When air enters the pleural cavity, pneumothorax occurs. There are the following types:

1. According to the mechanism of occurrence: pathological (lung cancer, abscess, penetrating wound of the chest) and artificial (treatment of tuberculosis).

2. Depending on which pleura is damaged, external and internal pneumothorax is isolated.

3. According to the degree of communication with the atmosphere, an open pneumothorax is distinguished, when the pleural cavity is constantly in communication with the atmosphere. Closed if there is a single entry of air. Valve, when inhaling air from the atmosphere enters the pleural fissure, and on exhalation the hole closes.

4. Depending on the side of the damage - unilateral (right-sided, left-sided), bilateral.

Pneumothorax is a life-threatening complication. As a result, the lung collapses and turns off from breathing. Valvular pneumothorax is especially dangerous.

Ticket 22

23. Hormonal regulation of calcium metabolism in the body. Parathyroid hormones, calcitonin, calcitriol, their functions

Simultaneously with the mechanism provided by the existence of exchangeable calcium salts in the bones, which acts as a buffer system in relation to the concentration of calcium ions in the interstitial fluid, both hormones (parathyroid hormone and calcitonin) begin to act within 3-5 minutes after a rapid change in the concentration of calcium ions. The rate of PTH secretion increases; as already explained, this triggers numerous mechanisms aimed at reducing the concentration of calcium ions. Simultaneously with the decrease in the concentration of PTH, the concentration of calcitonin increases in young animals and, probably, in small children (and in adults, but to a lesser extent). Calcitonin induces a rapid uptake of calcium into bone and possibly many cells in other tissues, so in very young animals an excess of calcitonin may cause high calcium ion concentrations to return to normal much faster than buffering alone can do. a system mediated by the mechanism of readily exchangeable calcium salts. In the case of a long-term excess of calcium or its deficiency, only the effects of PTH are really important in normalizing the concentration of calcium ions in the plasma. In the event of a long-term calcium deficiency in the diet, PTH can often stimulate the release of calcium from the bones in quantities sufficient to maintain normal plasma concentrations for one year, but it is clear that even this source of calcium can be depleted. According to the detectable effect, bones can be considered a buffer reserve of calcium, which is controlled by parathyroid hormone. If the bones run out of calcium as a source of calcium or, on the contrary, become overfilled with calcium, PTH and vitamin D will act as a long-term mechanism that controls the concentration of calcium in the extracellular fluid, which regulate calcium absorption in the intestine and its excretion in the urine.

If the parathyroid glands do not secrete enough parathyroid hormone, this leads to a decrease in the leaching of easily exchangeable calcium from the bones by osteocytes, with almost complete and widespread inactivation of osteoclasts. As a result, the absorption of calcium from the bones is so reduced that it leads to a decrease in the level of calcium in body fluids. Because calcium and phosphate are no longer leached out of the bones, bones usually remain strong.

Calcitonin- a peptide hormone consisting of 12 amino acids, the physiological function of which is to regulate the exchange of calcium and phosphorus. Interest in this hormone is due, first of all, to its participation in maintaining a relatively constant level of calcium.
The main and immediate factor that acts on the thyroid gland and activates the synthesis of calcitonin release. is the concentration of calcium in the blood serum. An increase in the level of calcium in the blood, especially its ionized form, enhances the secretion of calcitonin, and a decrease depresses it.
The mediated pathway of regulation of calcitonin secretion is associated with the secretion of gastrin and some other enthormones. A decrease in the level of calcium in the digestive tract promotes the secretion of gastrin, which, in turn, leads to an increase in the synthesis and release of calcitonin by the thyroid gland.
Calcitonin through specific receptors (in the bones, kidneys) acts on cAMP. As a result, first of all, bone resorption is inhibited and their mineralization is stimulated. In particular, it is manifested by a decrease in the level of calcium and phosphorus in the blood serum and excretion of hydroxyproline.

Parathyroid hormone (PGT) is a functional antagonist of calcitonin: the first provides an increase in the composition of calcium, and the second - its decrease. A low concentration of calcium in the blood plasma stimulates the entry of a significant amount of PTH into the blood. which increases the reabsorption of calcium in the tubules of the kidneys and the secretion of phosphates, and in bone tissue - the acceleration of the process of resorption and release of calcium into the intercellular space.
At the cell level, calcitonin affects the transport of calcium across its membrane. It stimulates the absorption of calcium by mitochondria and thereby delays the outflow of calcium from cells. This process is associated with the activity of adenosine triphosphoric acid (ATP) of the cell membrane and depends on the ratio of sodium and potassium. Calcitonin affects the organic composition of the bone: it inhibits the breakdown of collagen, which is manifested by a decrease in the excretion of hydroxyproline in the urine

Biomechanics of respiration. Biomechanics of inspiration.

Parameter name	Meaning
Article subject:	Biomechanics of respiration. Biomechanics of inspiration.
Rubric (thematic category)	Medicine

Rice. 10.1. Effect of contraction of the diaphragmatic muscle on the volume of the chest cavity. The contraction of the diaphragmatic muscle during inhalation (dashed line) causes the diaphragm to drop down, the abdominal organs to move down and forward. As a result, the volume of the chest cavity increases.

Enlargement of the chest cavity during inhalation occurs as a result of contraction of the inspiratory muscles: the diaphragm and the external intercostal muscles. The main respiratory muscle is the diaphragm, which is located in the lower third of the chest cavity and separates the chest and abdominal cavities. When the diaphragmatic muscle contracts, the diaphragm moves down and displaces the abdominal organs down and forward, increasing the volume of the chest cavity mainly vertically (Fig. 10.1).

Enlargement of the chest cavity during inhalation promotes contraction of the external intercostal muscles, which lift the chest up, increasing the volume of the chest cavity. This effect of contraction of the external intercostal muscles is due to the peculiarities of the attachment of muscle fibers to the ribs - the fibers go from top to bottom and from back to front (Fig. 10.2). With a similar direction of the muscle fibers of the external intercostal muscles, their contraction turns each rib around an axis passing through the articulation points of the rib head with the body and the transverse process of the vertebra. As a result of this movement, each underlying costal arch rises more than the superior one descends. Simultaneous upward movement of all costal arches leads to the fact that the sternum rises upward and anteriorly, and the volume of the chest increases in the sagittal and frontal planes. The contraction of the external intercostal muscles not only increases the volume of the chest cavity, but also prevents the chest from lowering down. For example, in children with underdeveloped intercostal muscles, rib cage decreases in size during diaphragmatic contraction (paradoxical movement).

Rice. 10.2. The direction of the fibers of the external intercostal muscles and the increase in the volume of the chest cavity during inspiration. a - contraction of the external intercostal muscles during inspiration raises the lower rib more than it lowers the upper rib. As a result, the costal arches rise up and increase (b) the volume of the chest cavity in the sagittal and frontal plane.

With deep breathing in inspiratory biomechanism, as a rule, auxiliary respiratory muscles are involved - sternocleidomastoid and anterior scalene muscles, and their contraction further increases the volume of the chest. Specifically, the scalene muscles elevate the upper two ribs, while the sternocleidomastoid muscles elevate the sternum. Inhalation is an active process and requires the expenditure of energy during the contraction of the inspiratory muscles, which is expended to overcome the elastic resistance against the rigid tissues of the chest, the elastic resistance of the easily extensible lung tissue, the aerodynamic resistance of the airways to the air flow, as well as to increase intra-abdominal pressure and the resulting displacement abdominal organs downwards.

Exhale at rest in humans, it is carried out passively under the action of the elastic recoil of the lungs, which returns the volume of the lungs to its original value. However, during deep breathing, as well as during coughing and sneezing, expiration must be active, and the decrease in the volume of the chest cavity occurs due to the contraction of the internal intercostal muscles and abdominal muscles. Muscle fibers internal intercostal muscles go relative to the points of their attachment to the ribs from the bottom up and back to the front. During their contraction, the ribs rotate around an axis passing through the points of their articulation with the vertebra, and each superior costal arch descends more than the inferior one rises. As a result, all costal arches, together with the sternum, descend downward, reducing the volume of the chest cavity in the sagittal and frontal planes.

When a person breathes deeply, contraction of the abdominal muscles in expiratory phase increases pressure in the abdominal cavity, which contributes to the displacement of the dome of the diaphragm upward and reduces the volume of the chest cavity in the vertical direction.

The contraction of the respiratory muscles of the chest and diaphragm during inspiration causes increase in lung capacity, and when they relax during exhalation, the lungs collapse to their original volume. The volume of the lungs, both during inhalation and exhalation, changes passively, since, due to their high elasticity and extensibility, the lungs follow changes in the volume of the chest cavity caused by the contraction of the respiratory muscles. This position is illustrated by the following model of the passive increase in lung capacity(Fig. 10.3). In this model, the lungs are considered as an elastic balloon placed inside a container made of rigid walls and a flexible diaphragm. The space between the elastic balloon and the container walls is airtight. This model allows you to change the pressure inside the tank when moving down the flexible diaphragm. With an increase in the volume of the container, caused by the downward movement of the flexible diaphragm, the pressure inside the container, i.e., outside the container, becomes lower than atmospheric pressure in accordance with the ideal gas law. The balloon inflates as the pressure inside it (atmospheric) becomes higher than the pressure in the container around the balloon.

Rice. 10.3. Schematic diagram of a model demonstrating passive inflation of the lungs when the diaphragm is lowered. When the diaphragm is lowered down, the air pressure inside the container becomes lower than atmospheric pressure, which causes the elastic balloon to inflate. P - atmospheric pressure.

Attached to human lungs that completely fill chest cavity volume, their surface and the inner surface of the chest cavity are covered with a pleural membrane. The pleural membrane of the surface of the lungs (visceral pleura) does not physically come into contact with the pleural membrane that covers the chest wall (parietal pleura) because between these membranes there is pleural space(synonym - intrapleural space), filled with a thin layer of fluid - pleural fluid. This fluid moistens the surface of the lobes of the lungs and promotes their sliding relative to each other during inflation of the lungs, and also facilitates friction between the parietal and visceral pleura. The fluid is incompressible and its volume does not increase when the pressure decreases. pleural cavity. For this reason, highly elastic lungs exactly repeat the change in the volume of the chest cavity during inspiration. The bronchi, blood vessels, nerves and lymphatics form the root of the lung, with which the lungs are fixed in the mediastinum. The mechanical properties of these tissues determine the main degree of effort, ĸᴏᴛᴏᴩᴏᴇ must develop the respiratory muscles during contraction in order to cause increase in lung capacity. Under normal conditions, the elastic recoil of the lungs creates an insignificant amount of negative pressure in a thin layer of fluid in the intrapleural space relative to atmospheric pressure. Negative intrapleural pressure varies in accordance with the phases of the respiratory cycle from -5 (exhalation) to -10 cm aq. Art. (inspiration) below atmospheric pressure (Fig. 10.4). Negative intrapleural pressure can cause a decrease (collapse) in the volume of the chest cavity, which the chest tissues counteract with their extremely rigid structure. The diaphragm, compared with the chest, is more elastic, and its dome rises under the influence of the pressure gradient that exists between the pleural and abdominal cavities.

In a state where the lungs do not expand and do not collapse (a pause, respectively, after inhalation or exhalation), there is no air flow in the airways and the pressure in the alveoli is equal to atmospheric pressure. In this case, the gradient between atmospheric and intrapleural pressure will exactly balance the pressure developed by the elastic recoil of the lungs (see Fig. 10.4). Under these conditions, the value of intrapleural pressure is equal to the difference between the pressure in the airways and the pressure developed by the elastic recoil of the lungs. For this reason, the more the lungs are stretched, the stronger the elastic recoil of the lungs will be and the more negative relative to atmospheric pressure is the value of intrapleural pressure. This happens during inspiration, when the diaphragm descends and the elastic recoil of the lungs counteracts the inflation of the lungs, and the intrapleural pressure becomes more negative. When inhaling, this negative pressure pushes air through the airways toward the alveoli, overcoming airway resistance. As a result, air enters from the external environment into the alveoli.

Rice. 10.4. Pressure in the alveoli and intrapleural pressure during the inspiratory and expiratory phases of the respiratory cycle. In the absence of air flow in the airways, the pressure in them is equal to atmospheric (A), and the elastic traction of the lungs creates pressure E in the alveoli. cavities up to -10 cm aq. Art., ĸᴏᴛᴏᴩᴏᴇ helps to overcome the resistance to air flow in the respiratory tract, and air moves from the external environment to the alveoli. The value of intrapleural pressure is due to the difference between the pressures A - R - E. When exhaling, the diaphragm relaxes and the intrapleural pressure becomes less negative relative to atmospheric pressure (-5 cm of water column). Alveoli, due to their elasticity, reduce their diameter, pressure E increases in them. The pressure gradient between the alveoli and the external environment contributes to the removal of air from the alveoli through the respiratory tract to the external environment. The value of intrapleural pressure is due to the sum of A + R minus the pressure inside the alveoli, i.e. A + R - E. A is atmospheric pressure, E is the pressure in the alveoli due to the elastic recoil of the lungs, R is the pressure that overcomes the resistance to air flow in the airways, P - intrapleural pressure.

When exhaling, the diaphragm relaxes and the intrapleural pressure becomes less negative. Under these conditions, the alveoli, due to the high elasticity of their walls, begin to decrease in size and push air out of the lungs through the respiratory tract. Airway resistance to airflow maintains positive pressure in the alveoli and prevents their rapid collapse. Τᴀᴋᴎᴍ ᴏϬᴩᴀᴈᴏᴍ, in a calm state during exhalation, the flow of air in the respiratory tract is due only to the elastic recoil of the lungs.

Pneumothorax. If air enters the intrapleural space, for example through a wound opening, a collapse occurs in the lungs, the chest increases slightly in volume, and the diaphragm descends as soon as the intrapleural pressure becomes equal to atmospheric pressure. This condition is called pneumothorax, in which the lungs lose their ability to follow the change. chest cavity volume during breathing movements. Moreover, during inhalation, air enters the chest cavity through the wound opening and exits during exhalation without changing the volume of the lungs during respiratory movements, which makes it impossible for gas exchange between the external environment and the body.

The process of external respiration due to changes in the volume of air in the lungs during the inspiratory and expiratory phases of the respiratory cycle. With calm breathing, the ratio of the duration of inhalation to exhalation in the respiratory cycle is on average 1:1.3. External respiration of a person is characterized by the frequency and depth of respiratory movements. Breathing rate a person is measured by the number of respiratory cycles for 1 minute and its value at rest in an adult varies from 12 to 20 in 1 minute. This indicator of external respiration increases with physical work, rising ambient temperature, and changes with age. For example, in newborns, the respiratory rate is 60-70 per 1 min, and in people aged 25-30 years, an average of 16 per 1 min. The depth of breathing is determined by the volume of inhaled and exhaled air during one respiratory cycle. The product of the frequency of respiratory movements by their depth characterizes the main value of external respiration - lung ventilation. A quantitative measure of lung ventilation is the minute volume of respiration - this is the volume of air that a person inhales and exhales in 1 minute. The value of the minute volume of breathing of a person at rest varies within 6-8 liters. During physical work in a person, the minute volume of breathing can increase by 7-10 times.

Rice. 10.5. The volumes and capacities of air in the lungs and the curve (spirogram) of changes in the volume of air in the lungs during quiet breathing, deep inspiration and expiration. FRC - functional residual capacity.

lung air volumes. IN respiratory physiology a unified nomenclature of lung volumes in humans has been adopted, which fill the lungs with calm and deep breathing in the inhalation and exhalation phase of the respiratory cycle (Fig. 10.5). The lung volume that is inhaled or exhaled by a person during quiet breathing is commonly called tidal volume. Its value during quiet breathing is on average 500 ml. Maximum amount air, ĸᴏᴛᴏᴩᴏᴇ can be inhaled by a person in excess of the respiratory volume, it is commonly called inspiratory reserve volume(average 3000 ml). The maximum amount of air, ĸᴏᴛᴏᴩᴏᴇ a person can exhale after a calm exhalation, is commonly called the expiratory reserve volume (average 1100 ml). Finally, the amount of air ĸᴏᴛᴏᴩᴏᴇ remains in the lungs after maximum exhalation is called the residual volume, its value is approximately 1200 ml.

The sum of two or more lung volumes is called lung capacity. Air volume in human lungs is characterized by inspiratory lung capacity, vital lung capacity and functional residual lung capacity. Inspiratory capacity (3500 ml) is the sum of tidal volume and inspiratory reserve volume. Vital capacity of the lungs(4600 ml) includes tidal volume and inspiratory and expiratory reserve volumes. Functional residual lung capacity(1600 ml) is the sum of expiratory reserve volume and residual lung volume. Sum lung capacity And residual volume It is customary to call the total lung capacity, the value of which in humans is on average 5700 ml.

When inhaling, the human lungs due to the contraction of the diaphragm and external intercostal muscles, they begin to increase their volume from the level, and its value during quiet breathing is tidal volume, and with deep breathing - reaches various values reserve volume breath. When exhaling, the volume of the lungs returns to the initial level of functional residual capacity passively, due to the elastic recoil of the lungs. If air begins to enter the volume of exhaled air functional residual capacity, which takes place during deep breathing, as well as when coughing or sneezing, then exhalation is carried out due to muscle contraction abdominal wall. In this case, the value of intrapleural pressure, as a rule, becomes higher than atmospheric pressure, which causes the highest airflow velocity in the respiratory tract.

When inhaling, an increase in the volume of the chest cavity is prevented elastic recoil of the lungs, the movement of the rigid chest, the abdominal organs and, finally, the resistance of the airways to the movement of air towards the alveoli. The first factor, namely the elastic recoil of the lungs, to the greatest extent prevents the increase in lung volume during inspiration.

Biomechanics of respiration. Biomechanics of inspiration. - concept and types. Classification and features of the category "Biomechanics of respiration. Biomechanics of inspiration." 2017, 2018.

Forced breath.

Transport of substances in the gastrointestinal tract.

Oral cavity- a small amount of essential oils.

Stomach- water, alcohol, mineral salts, monosaccharides.

Duodenum– monomers, FAs.

Jejunum– up to 80% monomers.

In the upper section monosaccharides, amino acids, fatty acids.

In the lower section- water, salt.

3. Biomechanics of inhalation and exhalation. Overcoming forces when exercising inhalation. Primary lung volumes and capacities

Respiration is a set of processes that result in the consumption of O 2, the release of CO 2 and the conversion of energy chemical substances into biologically useful forms.

Stages of the respiratory process.

1) Ventilation of the lungs.

2) Diffusion of gas in the lungs.

3) Transport of gases.

4) Exchange of gases in tissues.

5) Tissue respiration.

Biomechanics of active inspiration. Inhalation (inspiration) is an active process.

When inhaling, the chest expands in three directions:

1) in vertical- due to the reduction of the diaphragm and the lowering of its tendon center. While moving down internal organs;

2) in the sagittal direction - associated with contraction of the external intercostal muscles and the withdrawal of the end of the sternum forward;

3) in frontal- the ribs move up and out due to the contraction of the external intercostal and intercartilaginous muscles.

1) Provided by increased contraction of the inspiratory muscles (intercostal external and diaphragm).

2) Contraction of auxiliary muscles:

a) extensor thoracic region spine and fixing and abducting shoulder girdle back - trapezoid, rhomboid, raising the scapula, small and large pectoral, anterior dentate;

b) raising the ribs.

With forced inspiration, the reserve of the pulmonary system is used.

Inhalation is an active process, because when you inhale, the forces are overcome:

1) elastic resistance of muscles and lung tissue (combination of stretching and elasticity).

2) inelastic resistance - overcoming the force of friction when moving the ribs, the resistance of the internal organs to the diaphragm, the heaviness of the ribs, the resistance to air movement in the bronchi of medium diameter. Depends on the tone of the bronchial muscles (10–20 mm Hg in adults, healthy people). May increase to 100mm with bronchospasm, hypoxia.

The process of inhalation.

When inhaling, the volume of the chest increases, the pressure in the pleural space increases from 6 mm Hg. Art. increases to - 9, and with a deep breath - up to 15 - 20 mm Hg. Art. This is a negative pressure (i.e. below atmospheric pressure).

The lungs passively expand, the pressure in them becomes 2-3 mm lower than atmospheric pressure, and air enters the lungs.

There was a breath.

passive process. When the inhalation is over, the respiratory muscles are relaxed, under the influence of gravity, the ribs descend, the internal organs return the diaphragm to its place. The volume of the chest decreases, passive exhalation occurs. The pressure in the lungs is 3-4 mm higher than atmospheric pressure.

With forced exhalation, the internal intercostal muscles, the muscles that flex the spine and the abdominal muscles are involved.

The role of the surfactant.

It is a phospholipid substance produced by granular pneumocytes. The stimulus for its development are deep breaths.

During inhalation, the surfactant is distributed over the surface of the alveoli with a film 10–20 µm thick. This film prevents the alveoli from collapsing during exhalation because the surfactant increases the surface tension forces of the fluid layer lining the alveoli on inspiration.

When exhaling, it reduces them.

Pneumothorax- Air entering the pleural space.

Open;

Closed;

Unilateral;

Bilateral.

Thoracic and abdominal breathing.

More effective than abdominal, because intra-abdominal pressure increases and blood return to the heart increases.

4. Research methods for human reflexes: tendon (knee, Achilles), Ashner, pupillary.

Ticket number 4

1. Principles of coordination of reflex activity: the relationship of excitation and inhibition, the principle feedback, the principle of dominance.

Coordination is ensured by selective excitation of some centers and inhibition of others. Coordination is the unification of the reflex activity of the central nervous system into a single whole, which ensures the implementation of all body functions. The following basic principles of coordination are distinguished:

The principle of irradiation of excitations. The neurons of different centers are interconnected by intercalary neurons, therefore, impulses that arrive with strong and prolonged stimulation of the receptors can cause excitation not only of the neurons of the center of this reflex, but also of other neurons. Irradiation of excitation provides, with strong and biologically significant irritations, inclusion in the response more motoneurons.

The principle of a common final path. Impulses coming to the CNS through different afferent fibers can converge (converge) to the same intercalary, or efferent, neurons. The same motor neuron can be excited by impulses coming from different receptors (visual, auditory, tactile), i.e. participate in many reflex reactions (include in various reflex arcs).

dominance principle. It was discovered by A.A. Ukhtomsky, who discovered that irritation of the afferent nerve (or cortical center), which usually leads to contraction of the muscles of the limbs during overflow in the animal intestine, causes an act of defecation. In this situation, the reflex excitation of the defecation center "suppresses, inhibits the motor centers, and the defecation center begins to respond to signals that are foreign to it.

A.A. Ukhtomsky believed that in each this moment life, a determining (dominant) focus of excitation arises, subordinating the activity of the entire nervous system and determining the nature of the adaptive reaction. Excitations from different areas of the central nervous system converge to the dominant focus, and the ability of other centers to respond to signals coming to them is inhibited. Due to this, conditions are created for the formation of a certain reaction of the body to an irritant that has the greatest biological significance, i.e. satisfying a vital need.

In the natural conditions of existence, the dominant excitation can cover entire systems of reflexes, resulting in food, defensive, sexual and other forms of activity. The dominant excitation center has a number of properties:

1) its neurons are characterized by high excitability, which contributes to the convergence of excitations to them from other centers;

2) its neurons are able to summarize incoming excitations;

3) excitation is characterized by persistence and inertness, i.e. the ability to persist even when the stimulus that caused the formation of the dominant has ceased to act.

4. The principle of feedback. The processes occurring in the central nervous system cannot be coordinated if there is no feedback, i.e. data on the results of function management. Feedback allows you to correlate the severity of changes in system parameters with its operation. The connection of the output of the system with its input with a positive gain is called positive feedback, and with a negative gain - negative feedback. Positive feedback is mainly characteristic of pathological situations.

Negative feedback ensures the stability of the system (its ability to return to its original state after the influence of disturbing factors ceases). There are fast (nervous) and slow (humoral) feedbacks. Feedback mechanisms ensure the maintenance of all homeostasis constants.

5. The principle of reciprocity. It reflects the nature of the relationship between the centers responsible for the implementation of opposite functions (inhalation and exhalation, flexion and extension of the limbs), and lies in the fact that the neurons of one center, being excited, inhibit the neurons of the other and vice versa.

6. The principle of subordination (subordination). The main trend in the evolution of the nervous system is manifested in the concentration of the functions of regulation and coordination in the higher parts of the central nervous system - cephalization of the functions of the nervous system. There are hierarchical relationships in the central nervous system - the cerebral cortex is the highest center of regulation, the basal ganglia, the middle, medulla and spinal cord obey its commands.

7. The principle of function compensation. The central nervous system has a huge compensatory ability, i.e. can restore some functions even after the destruction of a significant part of the neurons that form the nerve center (see plasticity of the nerve centers). If individual centers are damaged, their functions can be transferred to other brain structures, which is carried out with the obligatory participation of the cerebral cortex. Animals that had their cortex removed after restoration of lost functions experienced their loss again.

With local insufficiency of inhibitory mechanisms or with excessive intensification of excitation processes in one or another nerve center, a certain set of neurons begins to autonomously generate pathologically enhanced excitation - a generator of pathologically enhanced excitation is formed.

With a high generator power, a whole system of non-ironal formations functioning in a single mode arises, which reflects a qualitatively new stage in the development of the disease; tight links between constituent elements of such a pathological system underlie its resistance to various therapeutic effects. Its essence lies in the fact that the structure of the central nervous system, which forms a functional premise, subordinates to itself those departments of the central nervous system to which it is addressed and forms a pathological system together with them, determining the nature of its activity. Such a system is biologically negative. If, for one reason or another, the pathological system disappears, then the formation of the central nervous system, which played leading role, loses its determinant value.

2. Digestion in the oral cavity and swallowing (its phases). Reflex regulation of these acts

Lecture Search

The respiratory muscles are the "engine" of ventilation. Calm and forced breathing differ in many ways, including the number of respiratory muscles that perform respiratory movements. Distinguish inspiratory(responsible for inhalation) and expiratory(responsible for exhalation) muscles. The respiratory muscles are also divided into main And auxiliary. TO main inspiratory muscles include: a) diaphragm; b) external intercostal muscles; c) internal intercartilaginous muscles.

Fig. 4. Mechanism of respiratory movements (change in the volume of the chest) due to the diaphragm and abdominal muscles (A) and contraction of the external intercostal muscles (B) (on the left - a model of the movement of the ribs)

With calm breathing, 4/5 of inspiration is carried out by the diaphragm. The contraction of the muscular part of the diaphragm, transmitted to the tendon center, leads to a flattening of its dome and an increase in the vertical dimensions of the chest cavity. With calm breathing, the dome of the diaphragm drops by about 2 cm. The internal intercostal and intercartilaginous muscles are involved in raising the ribs. They run obliquely from rib to rib from behind and above, anteriorly and downward (dorsocranial and ventrocaudal). Due to their contraction, the lateral and saggital dimensions of the chest increase. During quiet breathing, exhalation occurs passively with the help of elastic return forces (just like a stretched spring itself returns to initial position).

During forced breathing, the main inspiratory muscles are joined auxiliary: large and small chest, scalene, sternocleidomastoid, trapezius.

Fig.5. The most important accessory inspiratory muscles (A) and accessory expiratory respiratory muscles (B)

In order for these muscles to participate in the act of inhalation, it is necessary that their attachment sites are fixed. A typical example is the behavior of a patient with difficulty breathing. Such patients rest their hands on an immovable object, as a result of which the shoulders are fixed and tilt the head back.

Exhalation during forced breathing is provided expiratory muscles: main- internal intercostal muscles and auxiliary- muscles of the abdominal wall (external and internal oblique, transverse, straight).

Depending on whether the expansion of the chest during normal breathing is mainly associated with raising the ribs or flattening the diaphragm, there are chest (costal) and abdominal types of breathing.

Control questions

1. What muscles are the main inspiratory and expiratory muscles?

2. With the help of what muscles is a calm breath carried out?

3. What muscles are auxiliary inspiratory and expiratory?

4. What muscles are used for forced breathing?

5. What are thoracic and abdominal types of breathing?

Breathing resistance

The respiratory muscles perform work equal to 1–5 J at rest and provide overcoming the resistance to breathing and creating an air pressure gradient between the lungs and the external environment. With calm breathing, only 1% of the oxygen consumed by the body is spent on the work of the respiratory muscles (the central nervous system consumes 20% of all energy). Energy consumption for external respiration is insignificant, because:

1. when inhaling, the chest expands itself due to its own elastic forces and helps to overcome the elastic recoil of the lungs;

2. the external link of the respiratory system works like a swing (a significant part of the energy of muscle contraction goes into the potential energy of the elastic traction of the lungs)

3. little inelastic resistance to inhalation and exhalation

There are two types of resistance:

1) viscous inelastic tissue resistance

2) elastic (elastic) resistance of the lungs and tissues.

Viscous inelastic resistance is due to:

- aerodynamic resistance of the airways

Viscous tissue resistance

More than 90% of inelastic resistance is due to aerodynamic airway resistance (occurs when air passes through a relatively narrow part of the respiratory tract - the trachea, bronchi and bronchioles). As the bronchial tree branches to the periphery, the airways become narrower and narrower, and it can be assumed that it is the narrowest branches that provide the greatest resistance to breathing. However, the total diameter increases towards the periphery and the resistance decreases. So, at the level of generation 0 (trachea), the total cross-sectional area is about 2.5 cm2, at the level of terminal bronchioles (generation 16) - 180 cm2, respiratory bronchioles (from the 18th generation) - about 1000 cm2 and then > 10,000 cm2. Therefore, airway resistance is mainly localized in the mouth, nose, pharynx, trachea, lobar and segmental bronchi until approximately the sixth branching generation. Peripheral airways less than 2 mm in diameter account for less than 20% of breathing resistance. It is these departments that have the greatest extensibility ( C-compliance).

Compliance, or extensibility (C) - a quantitative indicator characterizing the elastic properties of the lungs

C= D V/ D P

where C is the degree of extensibility (ml / cm water column); DV - volume change (ml), DP - pressure change (cm water column)

The total compliance of both lungs (C) in an adult is about 200 ml of air per 1 cm of water. This means that with an increase in transpulmonary pressure (Ptp) by 1 cm of water. lung volume increases by 200 ml.

R= (RA-Rao)/V

where RA is alveolar pressure

Pao - pressure in the mouth

V is the volumetric ventilation rate per unit of time.

Alveolar pressure cannot be measured directly, but it can be derived from pleural pressure. Pleural pressure can be determined by direct methods or indirectly by integral plethysmography.

Thus, the higher V, i.e. the more we breathe, the greater the pressure difference should be at constant resistance. The higher, on the other hand, the airway resistance, the higher the pressure difference must be to obtain a given respiratory flow rate. inelastic breathing resistance depends on the lumen of the airways - especially the glottis, bronchi. The adductor and abductor muscles of the vocal folds, which regulate the width of the glottis, are controlled through the inferior laryngeal nerve by a group of neurons that are concentrated in the ventral region. respiratory group medulla oblongata. This neighborhood is not accidental: during inhalation, the glottis expands somewhat, while exhaling it narrows, increasing the resistance to air flow, which is one of the reasons for the longer duration of the expiratory phase. Similarly, the lumen of the bronchi and their patency change cyclically.

The tone of the smooth muscles of the bronchi depends on the activity of its cholinergic innervation: the corresponding efferent fibers pass through the vagus nerve.

A relaxing effect on bronchial tone is provided by sympathetic (adrenergic) innervation, as well as the recently discovered "non-adrenergic inhibitory" system. The influence of the latter is mediated by some neuropeptides, as well as microganglia found in the muscular wall of the airways; a certain balance between these influences contributes to the establishment of the optimal lumen of the tracheobronchial tree for a given air flow rate.

Dysregulation of bronchial tone in humans forms the basis of bronchospasm , resulting in a sharp decrease in airway patency (obstruction) and increased breathing resistance. The cholinergic system of the vagus nerve is also involved in the regulation of mucus secretion and the movements of the cilia of the ciliated epithelium of the nasal passages, trachea and bronchi, thereby stimulating mucociliary transport. - the release of foreign particles that have entered the airways. The excess mucus that is characteristic of bronchitis also creates an obstruction and increases breathing resistance.

The elastic resistance of the lungs and tissues includes: 1) elastic forces of the lung tissue itself; 2) elastic forces caused by the surface tension of the liquid layer on the inner surface of the walls of the alveoli and other airways of the lungs.

Collagen and elastic fibers woven into the parenchyma of the lungs create an elastic traction of the lung tissue. In collapsed lungs, these fibers are in an elastically contracted and twisted state, but when the lungs expand, they stretch and straighten out, while elongating and developing more and more elastic recoil. The magnitude of tissue elastic forces, which cause the collapse of the lungs filled with air, is only 1/3 of the total elasticity of the lungs.

At the interface between air and liquid, which covers the alveolar epithelium with a thin layer, surface tension forces arise. Moreover, the smaller the diameter of the alveoli, the greater the surface tension force. On the inner surface of the alveoli, the fluid tends to contract and squeeze air out of the alveoli towards the bronchi, as a result, the alveoli begin to collapse. If these forces acted unhindered, then thanks to the fistulas between the individual alveoli, the air from the small alveoli would pass into the large ones, and the small alveoli themselves would have to disappear. To reduce surface tension and preserve the alveoli in the body, there is a purely biological adaptation. This - surfactants(surfactants) acting as a detergent.

Surfactant is a mixture that essentially consists of phospholipids (90-95%), including primarily phosphatidylcholine (lecithin). Along with this, it contains four surfactant-specific proteins, as well as a small amount of carbon hydrate. The total amount of surfactant in the lungs is extremely small. There are about 50 mm3 of surfactant per 1 m2 of the alveolar surface. The thickness of its film is 3% of the total thickness of the airborne barrier. Surfactant is produced by type II alveolar epithelial cells. The surfactant layer reduces the surface tension of the alveoli by almost 10 times. The decrease in surface tension occurs due to the fact that the hydrophilic heads of these molecules bind strongly to water molecules, and their hydrophobic ends are very weakly attracted to each other and other molecules in solution. The repulsive forces of the surfactant counteract the attractive forces of the water molecules.

Surfactant Functions:

1) stabilization of the size of the alveoli in extreme positions - on inspiration and expiration

2) protective role: protects the walls of the alveoli from the damaging effects of oxidizing agents, has bacteriostatic activity, provides reverse transport of dust and microbes through the airways, reduces the permeability of the lung membrane (prevention of pulmonary edema).

Surfactants begin to be synthesized at the end of the intrauterine period. Their presence facilitates the first breath. In preterm labor, the baby's lungs may be unprepared for breathing. Surfactant deficiency or defects cause serious illness (respiratory distress syndrome). The surface tension in the lungs in these children is high, so many of the alveoli are in a collapsed state.

Control questions

1. Why is the energy consumption for external respiration insignificant?

2. What types of airway resistance are isolated?

3. What causes viscous inelastic resistance?

4. What is extensibility, how to determine it?

5. On what factors does viscous inelastic resistance depend?

6. What causes the elastic resistance of the lungs and tissues?

7. What are surfactants, what functions do they perform?

©2015-2018 poisk-ru.ru
All rights belong to their authors. This site does not claim authorship, but provides free use.
Copyright Violation and Personal Data Violation

Mechanism of external respiration. Biomechanics of inhalation and exhalation.

external respiration is the exchange of gases between the body and the environment. It is carried out using two processes - pulmonary respiration and respiration through the skin.

Pulmonary respiration consists in the exchange of gases between the alveolar air and the environment and between the alveolar air and the capillaries. During gas exchange with the external environment, air containing 21% oxygen and 0.03-0.04% carbon dioxide enters, and the exhaled air contains 16% oxygen and 4% carbon dioxide. Oxygen enters the alveolar air from atmospheric air, and carbon dioxide is released in the opposite direction.

When exchanging with the capillaries of the pulmonary circulation in the alveolar air, the oxygen pressure is 102 mm Hg. Art., and carbon dioxide - 40 mm Hg. Art., the tension in the venous blood of oxygen - 40 mm Hg. Art., and carbon dioxide - 50 mm Hg. Art. As a result of external respiration, arterial blood flows from the lungs, rich in oxygen and poor in carbon dioxide.

External respiration is carried out as a result of rhythmic movements of the difficult cell. The respiratory cycle consists of inspiratory and expiratory phases, between which there is no pause. At rest in an adult, the respiratory rate is 16-20 per minute.

inhale is an active process. With a calm breath, the external intercostal and intercartilaginous muscles contract. They lift the ribs, while the sternum moves forward. This leads to an increase in the sagittal and frontal dimensions of the chest cavity. At the same time, the muscles of the diaphragm contract. its dome descends, and the abdominal organs move down, to the sides and forward. Due to this, the chest cavity also increases in the vertical direction.

After the end of inhalation, the respiratory muscles relax - begins exhalation. Calm exhalation is a passive process.

During it, the chest returns to its original state under the influence of its own weight, stretched ligamentous apparatus and pressure on the diaphragm of the abdominal organs. With physical exertion, pathological conditions accompanied by shortness of breath (pulmonary tuberculosis, bronchial asthma, etc.), forced breathing occurs. Auxiliary muscles are involved in the act of inhalation and exhalation. With forced inspiration, the sternocleidomastoid, scalene, pectoral, and trapezius muscles additionally contract. They contribute to the additional lifting of the ribs. During forced exhalation, the internal intercostal muscles contract, which increase the descent of the ribs. Those. forced exhalation is an active process.

Pressure in the pleural cavity and its origin and role in the mechanism of external respiration. Changes in pressure in the pleural cavity in different phases of the respiratory cycle.

The pressure in the pleural cavity is always below atmospheric - negative pressure.

The value of negative pressure in the pleural cavity:

• by the end of maximum expiration - 1-2 mm Hg. Art.,
• by the end of a quiet exhalation - 2-3 mm Hg. Art.,
• by the end of a quiet breath - 5-7 mm Hg. Art.,
• by the end of the maximum breath - 15-20 mm Hg. Art.

The intensity of growth of the chest is higher than the tissue of the lungs. This leads to an increase in the volume of the pleural cavity, and since it is airtight, the pressure becomes negative.

Elastic recoil of the lungs- the force with which the tissue tends to fall.

The elastic recoil of the lungs is due to :

1) surface tension of the liquid film covering the inner surface of the alveoli;

2) the elasticity of the tissue of the walls of the alveoli due to the presence of elastic fibers in them;

3) the tone of the bronchial muscles.

1. Biomechanics of inhalation and exhalation

ZhEL and its components. Methods for their determination. Residual air.

The functioning of the external respiration apparatus can be judged by the volume of air entering the lungs during one respiratory cycle. The volume of air entering the lungs during maximum inhalation forms the total lung capacity. It is approximately 4.5-6 liters and consists of the vital capacity of the lungs and the residual volume.

Vital capacity of the lungs- the amount of air that a person can exhale after a deep breath. It is one of the indicators physical development organism and is considered pathological if it is 70-80% of the proper volume. During life, this value may change. It depends on a number of reasons: age, height, position of the body in space, food intake, physical activity presence or absence of pregnancy.

The vital capacity of the lungs consists of respiratory and reserve volumes. Tidal volume is the amount of air that a person inhales and exhales at rest. Its value is 0.3-0.7 liters. It maintains at a certain level the partial pressure of oxygen and carbon dioxide in the alveolar air. Inspiratory reserve volume is the amount of air that can be additionally inhaled by a person after a normal inhalation. As a rule, it is 1.5-2.0 liters. It characterizes the ability of lung tissue to additional stretching. The expiratory reserve volume is the amount of air that can be exhaled following a normal exhalation.

Residual volume- a constant volume of air in the lungs even after maximum exhalation. It is about 1.0-1.5 liters.

An important characteristic of the respiratory cycle is the frequency of respiratory movements per minute. Normally, it is 16-20 movements per minute. The duration of the respiratory cycle is calculated by dividing 60 s by the value of the respiratory rate.

The entry and expiration times can be determined from the spirogram.

Lung volumes:

1. Tidal volume (TO) = 500 ml

2. Inspiratory reserve volume (RIV) = 1500-2500 ml

3. Expiratory reserve volume (ERV) = 1000 ml

4. Residual volume (RO) = 1000 -1500ml

Lung capacity:

- total lung capacity (TLC) \u003d (1 + 2 + 3 + 4) \u003d 4-6 liters

- vital capacity of the lungs (VC) \u003d (1 + 2 + 3) \u003d 3.5-5 liters

- functional residual capacity of the lungs (FRC) \u003d (3 + 4) \u003d 2-3 liters

- inspiratory capacity (EV) \u003d (1 + 2) \u003d 2-3 liters

Minute volume of ventilation of the lungs and its changes under various loads, methods for its determination. "Harmful space" and effective pulmonary ventilation. Why rare and deep breathing is more effective.

Minute volume- the amount of air exchanged with the environment during quiet breathing. It is determined by the product of the tidal volume and the respiratory rate and is 6-8 liters.

Its value, on average, is 500 ml, the respiratory rate per minute is 12-16 and, therefore, the minute volume of breathing, on average, is 6-8 liters.

However, not all air entering the respiratory system takes part in gas exchange. Part of the air fills the airways (larynx, trachea, bronchi, bronchioles) and does not reach the alveoli, because it is the first to leave the body during exhalation.

This air is called air of harmful space. Its volume, on average, is 140-150 ml. Therefore, the concept of effective pulmonary ventilation is introduced. This is the amount of air per minute that takes part in gas exchange. Effective pulmonary ventilation at the same minute volume of breathing can be different. So, the larger the tidal volume, the smaller the relative volume of air in the harmful space. Therefore, rare and deep breathing is more effective for supplying the body with oxygen, as the ventilation of the alveoli increases.

Breathing, its main stages. Mechanisms of external respiration. Biomechanics of inhalation and exhalation.

Respiration is a complex continuous process, as a result of which the gas composition of the blood is constantly updated.

In the process of respiration, three links are distinguished: external, or pulmonary respiration, the transport of gases by blood, and internal, or tissue, respiration.

Respiration is a set of physiological processes that ensure the continuous supply of oxygen to tissues, its use in oxidative reactions, as well as the removal from the body of carbon dioxide and partially water formed during metabolism. The respiratory system includes the nasal cavity, larynx, bronchi and lungs. Breathing consists of the following main steps:

external respiration, which provides gas exchange between the lungs and the external environment;

gas exchange between alveolar air and venous blood flowing to the lungs;

transport of gases by blood; gas exchange between arterial blood and tissues;

tissue respiration.

External respiration is the exchange of gases between the body and the surrounding atmospheric air. It is carried out in two stages - the exchange of gases between atmospheric and alveolar air and gas exchange between the blood of the pulmonary capillaries and the alveolar air.

The respiratory apparatus includes the airways, lungs, pleura, chest skeleton and muscles, and the diaphragm. The main function of the external respiration apparatus is to provide the body with oxygen and release it from excess carbon dioxide. ABOUT functional state the external respiratory apparatus can be judged by the rhythm, depth, frequency of breathing, by the size of the lung volumes, by the indicators of oxygen uptake and carbon dioxide release, etc.

The transport of gases is carried out by the blood. It is provided by the difference in partial pressure (voltage) of gases along their path: oxygen from the lungs to the tissues, carbon dioxide from the cells to the lungs.

Internal or tissue respiration can also be divided into two stages. The first stage is the exchange of gases between the blood and tissues. The second is the consumption of oxygen by cells and the release of carbon dioxide by them (cellular respiration).

Inhale and Exhale

Inhalation begins with contraction of the respiratory (respiratory) muscles.

Muscles, the contraction of which leads to an increase in the volume of the chest cavity, are called inspiratory, and the muscles, the contraction of which leads to a decrease in the volume of the chest cavity, are called expiratory. The main inspiratory muscle is the diaphragm muscle. The contraction of the diaphragm muscle leads to the fact that its dome flattens, the internal organs are pushed down, which leads to an increase in the volume of the chest cavity in the vertical direction. The contraction of the external intercostal and intercartilaginous muscles leads to an increase in the volume of the chest cavity in the sagittal and frontal directions.

The lungs are covered with a serous membrane - the pleura, consisting of visceral and parietal sheets. The parietal layer is connected to the chest, and the visceral layer is connected to the lung tissue. With an increase in the volume of the chest, as a result of contraction of the inspiratory muscles, the parietal sheet will follow the chest. As a result of the appearance of adhesive forces between the sheets of the pleura, the visceral sheet will follow the parietal, and after them the lungs. This leads to an increase in negative pressure in the pleural cavity and an increase in lung volume, which is accompanied by a decrease in pressure in them, it becomes lower than atmospheric pressure and air begins to flow into the lungs - inspiration occurs.

Between the visceral and parietal layers of the pleura is a slit-like space called the pleural cavity. The pressure in the pleural cavity is always lower than atmospheric pressure, it is called negative pressure. The value of negative pressure in the pleural cavity is equal to: by the end of maximum expiration - 1-2 mm Hg. Art., by the end of a quiet exhalation - 2-3 mm Hg. Art., by the end of a quiet breath -5-7 mm Hg. Art., by the end of the maximum breath - 15-20 mm Hg. Art.

Negative pressure in the pleural cavity is due to the so-called elastic recoil of the lungs - the force with which the lungs constantly strive to reduce their volume. The elastic recoil of the lungs is due to two reasons:

Presence in the wall of the alveoli a large number elastic fibers;

The surface tension of the liquid film that covers the inner surface of the walls of the alveoli.

The substance that coats the inner surface of the alveoli is called surfactant.

Biomechanics of exhalation

The surfactant has a low surface tension and stabilizes the state of the alveoli, namely, when inhaling, it protects the alveoli from overstretching (the surfactant molecules are located far from each other, which is accompanied by an increase in the surface tension), and when exhaling, from falling down (the surfactant molecules are located close to each other). to each other, which is accompanied by a decrease in surface tension).

The value of negative pressure in the pleural cavity in the act of inspiration is manifested when air enters the pleural cavity, i.e., pneumothorax. If a small amount of air enters the pleural cavity, the lungs partially collapse, but their ventilation continues. This condition is called a closed pneumothorax. After a while, the air from the pleural cavity is sucked in and the lungs expand.

In case of violation of the tightness of the pleural cavity, for example, with penetrating wounds of the chest or with a rupture of lung tissue as a result of its defeat by some disease, the pleural cavity communicates with the atmosphere and the pressure in it becomes equal to atmospheric pressure, the lungs collapse completely, their ventilation stops. This pneumothorax is called open. Open bilateral pneumothorax is incompatible with life.

Partial artificial closed pneumothorax (introduction of a certain amount of air into the pleural cavity with a needle) is used for therapeutic purposes, for example, in tuberculosis, partial collapse of the affected lung promotes the healing of pathological cavities (caverns).

With deep breathing, a number of auxiliary respiratory muscles participate in the act of inhalation, which include: muscles of the neck, chest, back. The contraction of these muscles causes the ribs to move, which assists the inspiratory muscles.

During quiet breathing, the inhalation is active and the exhalation is passive. Forces for calm exhalation:

chest gravity;

Elastic traction of the lungs;

Pressure of the abdominal organs;

Elastic traction of costal cartilages twisted during inhalation.

In active expiration, the internal intercostal muscles, the serratus posterior inferior muscle, and the abdominal muscles take part.

Biomechanics of quiet inhalation and exhalation

Biology and genetics

Biomechanics of calm inhalation and exhalation Biomechanics of calm inspiration The contraction of the diaphragm and contraction of the external oblique intercostal and intercartilaginous muscles play a role in the development of quiet inspiration. Under the influence of a nerve signal, the diaphragm is most strong muscle inhalation, its muscles are located radially with respect to the tendon center; therefore, the dome of the diaphragm flattens by 1520 cm; with deep breathing, pressure in the abdominal cavity increases by 10 cm. Under the influence of a nerve signal, the external oblique intercostal and intercartilaginous muscles contract. At...

69. Biomechanics of calm inhalation and exhalation…

Biomechanics of quiet inspiration

In the development of a calm breath play a role:contraction of the diaphragm and contraction of the external oblique intercostal and intercartilaginous muscles.

Under the influence of a nerve signal aperture / strongest inspiratory musclecontracts, her muscles are locatedradial to tendon center, so the dome of the diaphragmflattens by 1.5-2.0 cm, with deep breathing - by 10 cmincreasing pressure in the abdominal cavity.The size of the chest increases in vertical size.

Under the influence of a nerve signal, they contractexternal oblique intercostal and intercartilaginous muscles. At muscle fiberplace of attachment tounderlying rib further from the spine than place it attachment to the overlying rib, That's why the moment of force of the underlying rib during contraction of this muscle is always greater than that of the overlying rib.This leads tothe ribs seem to rise, and the thoracic cartilaginous ends, as it were, are slightly twisted. Because when exhaling, the thoracic ends of the ribs are lowerthan vertebrates /arc at an angle/, then the contraction of the external intercostal musclesbrings them to a more horizontal position, the circumference of the chest increases, the sternum rises and comes forward, the intercostal distance increases. Rib cage not only rises, but alsoincreases its sagittal and frontal dimensions. Due contraction of the diaphragm, external oblique intercostal and intercartilaginous muscles increases the volume of the chest. The movement of the diaphragm causes approximately 70-80% of ventilation of the lungs.

Rib cage lined from the insideparietal pleurawith which it is firmly attached. Lung covered visceral pleura, with which it is also firmly fused. Under normal conditions, the pleura sheets fit snugly together and canto glide / thanks to the secretion of mucus/ relative to each other. The cohesive forces between them are great and the pleura cannot be separated.

When inhaling parietal pleurafollows the expanding chest, pullsvisceral leafand he stretches lung tissue , which leads to an increase in their volume. Under these conditions, the air in the lungs / alveoli / is distributed in a new, larger volume, this leads to a drop in pressure in the lungs. There is a pressure difference between the environment and the lungs /transrespiratory pressure/.

Transrespiratory pressure(P trr ) is the difference between the pressure in the alveoli (P alv) and external /atmospheric/ pressure (P external ). P trr \u003d R alv. - R external,. Equals to inhale - 4 mm Hg. Art.This difference makes one entera portion of air through the airways to the lungs. This is the breath.

Biomechanics of quiet exhalation

Calm exhalation is carried out passively , i.e. there is no muscle contraction, and the chest collapses due to the forces that arose during inhalation.

Reasons for exhalation:

1. Heaviness of the chest. The raised ribs are lowered by gravity.

2. The organs of the abdominal cavity, pushed down by the diaphragm during inspiration, raise the diaphragm.

3. Elasticity of the chest and lungs. Due to them, the chest and lungs take their original position

transrespiratoryend-expiratory pressure is=+ 4 mmHg

Biomechanics of forced inspiration

Forced inhalation is carried out through the participation additional muscles. In addition to the diaphragm and external oblique intercostal muscles, it involves the muscles of the neck, muscles of the spine, scapular muscles, serratus muscles.

Biomechanics of forced exhalation

Forced expiration is active. It is carried out by contraction of the muscles - internal oblique intercostal muscles, abdominal muscles.

As well as other works that may interest you
62488.		Painting the ornament at the husband's	14.21KB
	Tables of little ones from the images of the dewy ornament of the leaves of the fruit of the vichit of the servlet towels of the shirt. You already know that one of the types of arts and crafts is an ornament. Guess what kind of ornament.
62490.		Political power	28.05KB
	No other power has such opportunities. Detachment is the removal of the system of established domination from the really dominant one, which creates certain difficulties in establishing specific ruling forces ...
62495.		State	85.11KB
	Origin of the State. Functions of the state Types of form and types of the state The most significant events in the formation of the Belarusian statehood in the 90s of the 20th century The first question: The concept and features of the state.