Acetyl-l-carnitine - it is a special form of l-carnitine, an amino acid that can be independently synthesized in the body from amino acids - lysine and methionine. It is found in some quantity in red meat and dairy products. The acetyl group, which is part of Acetyl-L-Carnitine, is believed to play an important role in the production of acetylcholine, an important neurotransmitter.
AND instructions for use Lcarnitine
Acetyl-L-carnitine has been used effectively in the prevention and treatment of memory disorders, along with other supplements such as hyperzine A, ginseng, niacinamide, and fish oil.
A-L-C improves mental performance in older people with age-related memory problems. While early studies supported the benefits of acetyl-L-carnitine in the treatment of Alzheimer's disease and other forms of dementia, more recent studies have failed to confirm its effectiveness ( Hudson, CochraneDatabaseSystRev 2003). However, acetyl-L-carnitine helps people with mild cognitive impairment and early-stage Alzheimer's disease, study reports. Montgomery, IntClinPsychopharmacol, 2003.
Some research has been done with L-carnitine (not acetyl-L-carnitine) to see how it helps fight excess weight and burn fat, because it is precisely known that L-carnitine is involved in the transport of fatty acids into the mitochondria of cells for their use as fuel. However, efficacy for this purpose has not been demonstrated. A study in which moderately obese women were given 2 grams of L-carnitine daily for eight weeks showed no effect on body fat or body weight ( Villani, Int J Sport Nutr Excerc Metab 2000).
- improves symptoms of diabetic neuropathy and neuropathy associated with antiretroviral drug therapy given to people with HIV infection;
- reduces pain and improves mental health in people with fibromyalgia;
- in combination with propionyl-L-carnitine, helps with symptoms of age-related androgen deficiency in the elderly, sexual dysfunction, depression and fatigue;
- increase sperm motility in men with infertility;
- improve memory in chronic alcoholics;
- reduce the pain and slow progression of the disease in inflammation of the penis in Peyronie's disease ( Biagiotti, BJUInt., 2001);
- reduces hyperactivity in boys with fragile X syndrome;
We recommendsdosageand or how to take l-carnitine
Acetyl-L-carnitine is used in fairly large dosages, often measured in grams rather than milligrams (1000 mg = 1 gram):
For Alzheimer's disease, 1.5 to 4 g per day, usually divided into two or three doses throughout the day. With age-related memory impairment, use 1.5 to 2 g per day.
For diabetic neuropathy, 1.5 to 3 g daily in divided portions
For neuropathy associated with antiretroviral drug therapy, the dosage is 1 gram twice daily;
To reduce pain in fibromyalgia - 1.5 grams per day.
In infertile men, doctors have used 3 to 4 grams per day, sometimes in a mixture of acetyl-L-carnitine and L-carnitine, to improve sperm quality.
For Peyronie's disease, 2 grams divided into two doses throughout the day for 3 months;
To eliminate symptoms associated with age-related testosterone deficiency - 2 grams of acetyl-L-carnitine + 2 grams of propionyl-L-carnitine per day;
For boys with fragile X syndrome, the daily dosage to reduce hyperactivity is 20 to 50 mg/kg body weight.
What you need to know before choosingL-Carnitine
Different forms of carnitine are used for different purposes. Acetyl-L-carnitine is somewhat different from L-carnitine and propionyl-L-carnitine. Although the body can convert L-carnitine to acetyl-L-carnitine and vice versa, it is not known for certain whether whole molecule acetyl-L-carnitine is preferable, from its metabolites, or some other activated form. It is advisable not to replace one form of carnitine with another. There is another form of carnitine, D-carnitine, which should not be used as it can compete with other forms of carnitine and even cause carnitine deficiency symptoms.
TOget drunkL-Carnitine reviews and price review
| FAVORABLE OPTIONS AND PRICES OF L CARNITINE ON IHERB.COM | |||
|
NAME/PRICE |
Amount of substance in 1 capsule |
OTHER INGREDIENTS |
PRICE for 500 MG |
Doctor's Best®$19.88 /120 caps. |
500 mg |
Checked and approved ConsumerLab |
0.17$ |
MRM$6.58 /60 caps. |
500 mg |
Vitamin B6 |
0,11$ |
PrimaForce Acetyl-L-Carnitine$21.10 /250 gr. |
powder tasteless |
0,042$ |
|
Precautions and Side Effects
Alzheimer's disease and other types of age-related mental disorders are too serious diseases that should not be treated on their own. The symptoms of these diseases can be confused with other serious diseases, so it is necessary to consult a doctor before self-medicating severe memory disorders or cognitive problems.
Acetyl-L-carnitine, safe supplement but may cause gastrointestinal upset and nausea. It may also lead to the fishy smell of urine, breath or sweat.
Acetyl-L-carnitine should be used with caution in people taking blood-thinning medications, as it could theoretically increase the anticoagulant effect.
People with low or borderline low levels of thyroid hormones should not take acetyl-L-carnitine and other forms of carnitine as it can impair thyroid function. This is common among women over 60 years of age. Conversely, in cases of hyperthyroidism, taking acetyl-L-carnitine and other forms of carnitine may be helpful. ( Benvenga, Ann NY Acad Sci 2004).
Persons on dialysis should not take carnitine without medical supervision.
Some studies show that the use L-carnitine has contributed to the treatment of certain cardiovascular diseases. However, it has recently been found that people who eat red meat (such as beef) can accumulate microbes in their intestines that break down L-carnitine to trimethylamine (TMA), which is then absorbed into the bloodstream and can be converted in the liver into a substance called trimethylamine-N-oxide (TMAO). TMAO reduces the degree of cholesterol clearance from blood vessels, which in turn can cause hardening of the arteries and atherosclerosis ( koeth,Nature Medicine, 2013). It has been verified that vegetarians and vegans do not have this reaction, as don't eat meat. Supplementation with L-carnitine (and acetyl-L-carnitine due to their chemical similarity, since both contain a TMA moiety) could potentially promote the growth of these organisms by increasing TMAO levels, which could have negative effects on the cardiovascular system in long term. Therefore, unless you have a medical need to take L-carnitine (or acetyl-L-carnitine), it would be wiser to avoid its long-term use, especially at high doses.
Be sure to check with your doctor before using any L-carnitine supplements or medications.
