Acetyl-l-carnitine - this is a special form of l-carnitine, an amino acid that can be independently synthesized in the body from amino acids - lysine and methionine. Found in some quantities in red meat and dairy products. The acetyl group found in Acetyl-L-Carnitine is believed to play an important role in the production of acetylcholine, an important neurotransmitter.
AND instructions for use Lcarnitine
Acetyl-L-carnitine has been used effectively to prevent and treat memory disorders, along with other supplements such as huperzine A, ginseng, niacinamide and fish oil.
A-L-C improves mental performance in older adults with age-related memory problems. While early studies supported the benefits of acetyl-L-carnitine in treating Alzheimer's disease and other forms of dementia, more recent studies have failed to confirm its effectiveness ( Hudson, CochraneDatabaseSystRev 2003). However, acetyl-L-carnitine helps people with mild cognitive impairment and early stages of Alzheimer's disease, study reports Montgomery, IntClinPsychopharmacol, 2003.
Some studies have been done with L-carnitine (not acetyl-L-carnitine) to look at how it helps fight excess weight and burn fat, because It is known for sure that L-carnitine is involved in the transport of fatty acids into the mitochondria of cells for their use as fuel. However, the effectiveness of use for this purpose has not been demonstrated. A study in which moderately obese women were given 2 grams of L-carnitine daily for eight weeks showed no effect on the amount of subcutaneous fat or body weight ( Villani, Int J Sport Nutr Excerc Metab 2000).
- improves symptoms of diabetic neuropathy and neuropathy associated with antiretroviral drug therapy prescribed to people with HIV infection;
- reduces pain and improves mental health in people with fibromyalgia;
- in combination with propionyl-L-carnitine, helps with symptoms of age-related androgen deficiency in the elderly, sexual dysfunction, depression and fatigue;
- increase sperm motility in men with infertility;
- improve memory in chronic alcoholics;
- reduce pain and slow progression of the disease in inflammation of the penis in Peyronie's disease ( Biagiotti, BJUInt., 2001);
- reduces hyperactivity in boys with fragile X syndrome;
We recommendsdosageand or how to take l-carnitine
Acetyl-L-carnitine is used in fairly large dosages, often measured in grams rather than milligrams (1000 mg = 1 gram):
For Alzheimer's disease, 1.5 to 4 g per day, usually divided into two or three doses throughout the day. For age-related memory deterioration, use 1.5 to 2 g per day.
For diabetic neuropathy, 1.5 to 3 g per day in divided doses
For antiretroviral drug therapy-associated neuropathy, the dosage is 1 gram twice daily;
To reduce pain in fibromyalgia - 1.5 grams per day.
In infertile men, to improve sperm quality, doctors have used 3 to 4 g per day, sometimes in a mixture of acetyl-L-carnitine and L-carnitine.
For Peyronie's disease, 2 grams divided into two doses throughout the day for 3 months;
To eliminate symptoms associated with age-related testosterone deficiency - 2 grams of acetyl-L-carnitine + 2 grams of propionyl-L-carnitine per day;
For boys with fragile X syndrome, the daily dosage to reduce hyperactivity is 20 to 50 mg/kg body weight.
What you need to know before you chooseL-Carnitine
Different forms of carnitine are used for different purposes. Acetyl-L-carnitine is somewhat different from L-carnitine and propionyl-L-carnitine. Although the body can convert L-carnitine to acetyl-L-carnitine and vice versa, it is not known exactly whether acetyl-L-carnitine is preferred from the whole molecule, from its metabolites, or some other activated form. It is advisable not to replace one form of carnitine with another. There is another form of carnitine, D-carnitine, this should not be used as it may compete with other forms of carnitine and even cause symptoms of carnitine deficiency.
TOget drunkL-Carnitine, reviews and price review
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Precautions and side effects
Alzheimer's disease and other types of age-related mental disorders are too serious illnesses that should not be treated on their own. Symptoms of these diseases can be confused with other serious illnesses, so you should consult a doctor before self-medicating severe memory disorders or cognitive problems.
Acetyl-L-Carnitine, a safe supplement, but may cause gastrointestinal disorders and nausea. This may also lead to to a fishy odor in urine, breath or sweat.
Acetyl-L-carnitine should be used with caution in people taking blood thinning medications, as it may theoretically increase the anticoagulant effect.
People with low or borderline low thyroid hormone levels should not take acetyl-L-carnitine and other forms of carnitine as it may impair thyroid function. It is common among women over 60 years of age. Conversely, in cases of hyperthyroidism, taking acetyl-L-carnitine and other forms of carnitine may be beneficial. ( Benvenga, Ann NY Acad Sci 2004).
People on dialysis should not take carnitine without a doctor's supervision.
Some studies show that use L-carnitine has contributed to the treatment of some cardiovascular diseases. However, it was recently discovered that people who eat red meat (such as beef) may accumulate microbes in their intestines that break down L-carnitine to trimethylamine (TMA), which is then absorbed into the bloodstream and can be converted by the liver into a substance called trimethylamine-N-oxide (TMAO). TMAO reduces the degree to which blood vessels are cleared of cholesterol, which in turn can cause hardening of the arteries and atherosclerosis ( Koeth,NatureMedicine, 2013). It has been verified that vegetarians and vegans do not have this reaction because... don't eat meat. Supplementation with L-carnitine (and acetyl-L-carnitine due to their chemical similarity as both contain a TMA moiety) may potentially promote the growth of these organisms by increasing TMAO levels, which may have negative cardiovascular effects in long term. Therefore, unless there is a medical need for you to take L-carnitine (or acetyl-L-carnitine), it may be wiser to avoid its long-term use, especially in large dosages.
Be sure to consult your doctor before using any l-carnitine supplements or medications.
